ASSESSMENT OF THE ACUTE TOXICITY FOR ETHANOLIC EXTRACT OF POLYHERBAL FORMULATION IN SWISS ALBINO MICEAbstract
The main objective of this study was to Assessment of the acute toxicity of ethanolic extract of Polyherbal formulation in Swiss albino mice. In this study, the acute oral toxicity study of ethanolic extract of PHF1 was carried out according to Organization for Economic Co-operation and Development (OECD) guideline 423 and 407 on Swiss albino mice (20–30 g). In the study, the oral dose of 2000 mg/kg of PHF1 extract was administered in the treated group. General behavior, morbidity, and mortality were determined up to 72 h and compared to control group. Further animals were investigated for a period of 3days assess any other toxic effect. Behavioral changes and other parameters such as body weight, hematological parameters, and biochemical parameters were evaluated and compared to the normal group. The result of the study was mentioned that In acute toxicity study, treatment groups revealed neither morbidity nor mortality or any significant changes in behavior only drowsiness, sedation, and lethargy were observe in the group having 2000 mg/kg of Polyherbal formulations extract. In the acute toxicity study, no change in organ weight, hematological, biochemical parameters were observed when compared to the control group. The result concluded that the oral administration of Polyherbal formulations extract didn’t produce any significant toxic effect in Swiss albino mice. Hence, Polyherbal formulations extract can be utilized safely for the treatment of Parkinson’s disease (PD).
A. K. Srivastava *, A. Naseer, A. Gupta, B. Chauhan and R. Sanwal
Adarsh Vijendra Institute of Pharmaceutical Sciences, Shobhit University, Gangoh, Uttar Pradesh, India.
22 June 2020
15 October 2020
04 May 2021
01 June 2021