ASSESSMENT OF VITAMIN D ON METABOLIC DISORDERS IN ARTHRITIC PREDIABETIC PATIENTS- A PHARMACOLOGICAL APPROACH

We planned to clarify the association between the Vitamin D supplementation and predisposition of metabolic syndrome including obesity, diabetes mellitus, hypertension and dyslipidemia in arthritic patient with pre diabetic condition and to assess prediabetes interfere in the disease progression. Retrospective observational study was conducted on 236 patients. Of these, Arthritis patients with no co-morbid condition and not supplemented with Vitamin D (47), Arthritis patients supplementing with Vitamin D (63), Arthritis patients with prediabetic condition (68), Arthritic prediabetic patients supplementing with Vitamin D (58) were recruited based on inclusion and exclusion criteria. All anthropometric parameters and clinical findings were recorded the predominance of women with RA was observed in this study and the body weight was increased substantially in entire study group irrespective of gender. A significant increase in metabolic parameters was observed in patients with arthritis who were off of Vitamin D supplementation (p<0.05). On the other hand no such significant increase was observed in vitamin D supplemented group (p>0.05. In the group of arthritic patients with prediabetes condition significant increase in metabolic parameters (p<0.01). There was no deterioration rather an improvement during the Vitamin D supplementation in prediabetic arthritic patients but lipid parameters were increased gradually in continuous visit. Predisposition of metabolic disorder was reduced with Vitamin D supplement. Prediabetes has shown positive correlation with the disease activity in RA patients. Moreover less association was observed between the lipid profile and Vitamin D status.