ATTENUATION OF HEMODYNAMIC RESPONSE DURING LARYNGOSCOPY AND ENDOTRACHEAL INTUBATION WITH TWO DIFFERENT DOSES OF LABETALOL IN CONTROLLED HYPERTENSIVE PATIENTS

Aim: The aim of the present study was to compare the efficacy of two different doses of labetalol for controlling these hemodynamic responses to laryngoscopy and tracheal intubation in controlled hypertensive patients. Material and Methods: Present study conducted on 90 patients posted for various elective surgeries under general anesthesia at our institute. Study populations were randomly divided into 3 groups. Group L1: Received Inj Labetalol 0.15 mg/kg iv 5 min before intubation, Group L2: Received Inj. Labetalol 0.3 mg/kg iv 5 min before intubation and Group C: Received 0.9% normal saline iv 5 min before intubation. Heart rate (HR), systolic blood pressure (SBP) and diastolic blood pressure (DBP) were recorded prior to induction, at time of intubation and various intervals after intubation. Results: The control in HR, SBP, DBP, MAP and RPP was statistically significant between Group L1 and Group L2 at 3 min, 5 min post intubation. There was significant difference in HR throughout study time between L1 C and L2 C. Conclusion: Labetalol in both doses is effective in reducing the hemodynamic stress response in controlled hypertensive patients in dose dependent manner during laryngoscopy and tracheal intubation and was attenuated more with Labetalol 0.3mg/kg iv compared to 0.15mg/kg iv dosage.