BINUCLEAR Fe(III), Co(II), Ni(II), Cu(II) AND ZN(II) COMPLEXES WITH SCHIFF BASE 4, 4-(1, 4-PHENYLENE BIS(AZAN-1-YL-1- YLIDENE)) BIS(METHAN-1-YL-1-1-YLIDENE)-1, 2-DIOL. SYNTHESIS, CHARACTERIZATION AND BIOLOGICAL EVALUATION
AbstractCondensation reaction of 1, 4-phenylene diamine and Protochatechu aldehyde in 1:2 molar ratio resulted in the formation of new Schiff base ligand 4, 4–(1,4-phenylene bis(azan-1-yl-1-ylidene))bis(methan-1-yl-1-1-ylidene)-1, 2-diol; (H4L) .From the direct reaction of the ligand (1) with Co(II), Ni(II) and Cu(II) chlorides and Fe(III) and Zn(II)nitrates in 2M:1L molar ratio, the five new neutral complexes were prepared. The characterization of the newly formed compounds was done by 1HNMR, U.V-Vis and IR spectroscopy and elemental analysis. The data showed tetrahedral geometry for Co, Ni, Cu and Zn complexes (3, 4, 5 and 6 respectively) and octahedral geometry for Fe complex (2). The in-vitro antibacterial activity against G+ve bacteria (B. subtillus and S. aureus), G -ve bacteria (E. coli and P. aeruginosa) and antifungal activity against (C. albicans and A. niger) of the metal complexes were studied and compared with that of free ligand. Also MIC of the compounds against test microorganisms were detected.
Article Information
45
3851-3860
1696KB
1023
English
Ijpsr
Amr Nassar*, Ali Hassan, Yahiya Ahmed and Ahmed Elkmash
Chemistry Department, Faculty of Science (Boys), Al-Azhar University, Nasr City, Cairo, Egypt
nassar_tanta@yahoo.com
15 March, 2012
25 July, 2012
27 September, 2012
http://dx.doi.org/10.13040/IJPSR.0975-8232.3(10).3851-60
01 October, 2012
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