BIOGENIC SYNTHESIS OF MYCONANOPARTICLES FROM MUSHROOM EXTRACTS AND ITS MEDICAL APPLICATIONS: A REVIEW
HTML Full TextBIOGENIC SYNTHESIS OF MYCONANOPARTICLES FROM MUSHROOM EXTRACTS AND ITS MEDICAL APPLICATIONS: A REVIEW
N. Prabhu *, S. Karunakaran, S. Karthika Devi, R. Ravya, P. Subashree and M. Senthil Vadivu
Department of Biotechnology, Vivekanandha College of Engineering for Women, Elayampalayam, Tiruchengode - 637205, Tamil Nadu, India.
ABSTRACT: Mushroom extracts such as proteins, amino acids, polysaccharides and vitamins implicated as the reducing, stabilizing and capping agents in synthesis of myconanoparticles. Therefore, it is just a little attempt to study the journalism of this important of myconanoparticle. For this literature survey, basically library data was collected and digital resources were also included. From these sources we obtained reliable information about diverse nanoparticle synthesis from different mushroom species. Myconanotechnology is used in numerous medical applications like diagnosis of various diseases, therapeutic field and other applications like catalysis of bio molecules, microelectronics, biosensing devices, air and water purifiers and paints. Studies by different researchers specify that myconanoparticles possesses various pharma-cological activities such as antimicrobial activity, anticancer activity, anti-proliferative activity, and various other effects like antioxidant activity, cellular uptake, catalytic activity etc. There are many literatures demonstrating the various global uses of myconanoparticles. Till date very inadequate information is available from different sources so, we try to assemble this information in one review article. This review article gives an account of updated information on synthesis of various nanoparticles from different species of mushroom extracts and its optimal synthesizing factors and its medical significance.
Keywords: |
Silver, Gold, Other nanoparticles, Mycosynthesis, Effect of various factors
INTRODUCTION: In latest years, nano-technology is the fast-growing modern science, which has blossomed the human beings in the field of medical, chemical and physical sciences. In this field, synthesis of nanoparticles with erratic size, shape, chemical composition and prohibited poly-dispersity. It has vigorously developed as an important field of modern research with probable effects in electronic and medicine 1.
Compared to the large particles of bulk materials nanoparticle has novel characteristics because it is tremendously small in size and large surface to volume ratio. Oyster mushroom is considered safe for most people to eat because it is grown in controlled, sterilized environments.
Medicinal mushrooms have been in use for thousands of years. However, it has been only recently that the medicinal values of mushrooms have started to flourish in the western world. Mushrooms are tremendously high in fiber and contain high levels of vitamins such as thiamine, riboflavin, niacin, biotin, ascorbic acid, cobalamins, and minerals like potassium and phosphorus. Recently, medicinal mushrooms have come beneath close examination as a “wonder drug” of the 21st century. There have been claims that mushrooms augment the immune system, inhibit the growth of tumors, and help in eliminating the body of cancer and pathogens. Most of the superior researches are mainly focused on metal nanoparticles synthesized from the mushroom. Recent researches are terminate that large production of nanoparticle is reachable in fungi when compared to bacteria, because it produces large amount of enzymes dependable for nanoparticle production 2 and also using of their extracts viz. proteins, amino acids, polysaccharides and vitamins plays an major role as tumbling, stabilizing and capping agents in the process of the nanoparticles 3.
Naturally and artificially producing mushroom indicates that it could be expensive sources of antioxidant, anti-inflammatory, antiviral, anti-bacterial, cardiovascular, hepatoprotective and hypotensive activities in biological system 4 sizes and shape of nanoparticles depends on the preparation temperature and type of mushroom extract. The synthesis of nanoparticles from edible mushroom must be non-toxic for producing drugs. Novel biomaterials were used to biosynthesize of newly metallic nanoparticles bio resources 5.
Nanoparticles of noble metals, viz. gold, silver, platinum, and zinc are widely applied in fast moving consumer goods such as toothpaste, soaps, detergents, shoes, cosmetic products and besides their applications in medical and pharmaceutical products. Synthesis of nanoparticles can be performed using several habitually used chemical and physical methods and using fungus Fusarium, Oxysporum, Verticillium sp. Nano-particles can be synthesized using an array of methods including physical, chemical, biological, and hybrid techniques 6, 7, 57 Fig. 1.
The present review emphasizes reported mushroom resources for the synthesis of different myco-nanoparticles because edible mushroom has various therapeutic compounds which of being exploited since ancient time as traditional medicine. Here biosynthesis of extra and intracellular synthesis of glyconanoparticles process has been reported 5.
MATERIALS AND METHODS: For this study, fundamentally library data was collected, and digital resources such as Google Scholar, Scopus, PubMed, and Research gate, etc. also helped for this literature survey method. Through different journals of synthesis of nanoparticles, books we could gain recent information to continue this work. From these resources, we have reviewed the various works related to synthesis of myco-nanoparticles by using different species of mushroom, mechanism of synthesis and effect of various factors on psychosynthesis of nanoparticles, which are given below.
RESULTS AND DISCUSSION: Biosynthesis of different nanoparticles, the effect of various factors on biosynthesis of glyconanoparticles and mechanism behind mycosynthesis is summarized below.
Biosynthesis of Nobel Metal Nanoparticles by Mushroom: Recently, magnification of nano-particles synthesis in an ecological process is rising. Huang et al., reported that the nanoscience and technology field has numerous potential applications in many areas such as drug and gene delivery, diagnosis, tissue engineering, artificial implants, medical diagnostic and chemical, textile, materials industries 8. Maurya et al., reported that synthesis of nanoparticles might be moreover intracellular or extracellular and it’s also most favorite during downstream processing as it is cost effectual and less laborious during industrial applications. During nanoparticles synthesis, light plays a key role that the light-sensitive riboflavin presents in mushroom extract plays a major role in the decline process 9.
Mustafa Nadhim Owaid et al., reported that a broad variety of mushrooms consists of proteins and polysaccharides that have been utilized in both intracellular and extracellular gold and silver nanoparticles. It has been reported that using extracts of different mushroom species viz.
Agaricus bisporus, Lentinula edodes, Pleurotus florida, Pleurotus sajor caju, Agrocybe aegerita, Ganoderma lucidium, and Volvoriella volvaceae, etc. confirmed their perspective in reducing in silver ions into silver nanoparticles as well as converting gold ions into gold nanoparticles 10. The current report on, mycosynthesis of noble metal nanoparticles have been summarized in Table 1, 2. Application of nanoparticles synthesized from mushroom has been summarized in Table 5.
Silver Nanoparticles: Silver nanoparticles have been proved to be most effectual to restrain the bacterial and fungal growth due to the synthesis of secure and potent nanoparticles. Mirunalini et al. reported that the biosynthesis of silver nanoparticles was approved by using different parts of the mushroom through silver nitrate 12. Dhanasekaran et al. reported that mycosynthesis of the silver nanoparticle is an earlier and most resourceful elementary method have shown powerful antimicrobial activities; thus nanoparticles can be considered for the use in many medicinal drugs. Mushroom AgNPs have a spherical, core-shell shape; the size ranges from 10 to 70 nm 13. Sudhakar et al., and Sanghi et al., reported that AgNPs were visually detected due to the color change from yellow to dark brown of the reaction suspension, cell-free filtrate and silver nitrate using SMS showed an organic surface that reduces Ag+ and stabilizes the Ag-NPs by using a buried mushroom protein 14, 15. Narayanan et al., reported that exceedingly concentrated silver nanoparticles obtained from the aqueous extract from the fruit body of Agaricus bisporus 74. Some other silver nanoparticles produced by mushroom are listed in Table 1.
TABLE 1: MYCOSYNTHESIS OF SILVER NANOPARTICLES
Mushroom | Part used | Localization | Nanoparticle type | Size | Shape | Reference |
Agaricus bisporous | Fruiting Body | Intracellular | Ag | 15-20 nm | Spherical | 11 |
Agaricus bisporous | Fruiting Body | Intracellular | Ag | 80-100 nm | Spherical | 12 |
Agaricus bisporous | Fruiting Body | Extracellular | Ag | - | - | 13 |
Agaricus bisporous | Fruiting Body | Extracellular | Ag | 30 nm | Spherical | 14 |
Agaricus bisporous | Fruiting Body | Extracellular | Ag | 10-20 nm | Spherical | 13 |
Calocybe indica | Fruiting Body | Intracellular | Ag | 100nm | Spherical | 12 |
Coriolus Versicolor | Fruiting Body | Intracellular | Ag | 10 nm | Spherical | 15 |
Lentinula edodes | Fruiting Body | Extracellular | Ag | - | - | 2 |
Agaricus bisporous | Fruiting Body | Extracellular | Ag | 20-44 nm | Dispersed | 1 |
Helvella lacunose | Fruiting Body | Extracellular | Ag | 8-50 nm | - | 11 |
Ganoderma appalanatum | Fruiting Body | Extracellular | Ag | 15-20 nm | - | 16 |
Pleurotus florida | Fruiting Body | Extracellular | Ag | 20-50 nm | - | 17 |
Fomes fomenterieus | Fruiting Body | Extracellular | Ag | 8-50 nm | - | 2 |
Pleurotus sajor caju | Fruiting Body | Extracellular | Ag | 5-50 nm | - | 11 |
Agrocybe aegerita | Fruiting Body | Extracellular | Ag | - | - | 18 |
Ganoderma applanatum | Fruiting Body | Extracellular | Ag | 3-15 nm | Spherical | 19 |
Ganoderma lucidium | Fruiting Body | Extracellular | Ag | 10-70 nm | Spherical | 20 |
Pleurotus citrinopileatus | Fruiting Body | Extracellular | Ag | 6-10 nm | Core-shell | 9 |
Ganoderma neo-japonicum | Fruiting Body | Extracellular | Ag | 5-8 nm | Spherical | 21 |
Pleurotus florida | Fruiting Body | Extracellular | Ag | 20 ± 5 nm | - | 16 |
Volvariella volvacea | Fruiting Body | Extracellular | Ag | 5 nm | - | 22 |
Ganoderma neo-japonicum | Fruiting Body | Extracellular | Ag | 10-70 nm | - | 20 |
Pleurotus ostreatus (grey) | Fruiting Body | Intracellular | Ag | - | - | 10 |
Pleurotus ostreatus (white) | Fruiting Body | Extracellular | Ag | - | - | 10 |
P. comucopiae var. citrinopileatus (bright yellow) | Fruiting Body | Intracellular
|
Ag | 10-20 nm | Spherical
|
23 |
P. salmoneostramineus (pink) | Fruiting Body | Extracellular | Ag | - | - | 10 |
Agaricus bisporous | Fruiting Body | Extracellular | Ag | 5-50 nm | Spherical | 2 |
Calocybe indica | Fruiting Body | Extracellular | Ag | 5-50 nm | Spherical | 2 |
Pleurotus florida | Fruiting Body | Extracellular | Ag | 5-50 nm | Spherical | 2 |
Pleurotus platypus | Fruiting Body | Intracellular | Ag | 5-50 nm | Spherical | 2 |
Tricholoma matsutake | Fruiting Body | Extracellular | Ag | 10-20 nm | - | 24 |
Schizophyllum commune | Fruiting Body | Schizophyllan | Ag | - | - | 25 |
Pleurotus florida | Fruiting Body | Extracellular | Ag | 20 ± 5 nm | Spherical | 26 |
Gold Nanoparticles: Bhat et al., reported that the synthesis of gold nanoparticles from mushrooms are a more gorgeous member of novel metal nano-particles because of their prospective applications in the fields ranging from catalysis, nonlinear optics, nanoelectronics, gene expression, and disease diagnosis 75. Zhang et al., reported that mushroom gold nanoparticles have spherical, hex-agonal and triangular shapes with sizes ranging from 5 to 150 nm whereas those of the fungus Flammulina velutipes have a size ≤ 20 nm 76. Sen LK et al., reported that mycosynthesis of gold nanoparticles have diverse shapes such as spherical, triangular, hexagonal, crystal, etc.
In this article reported that mycosynthesizes Au-NPs are spherical and triangular with a varying size of 10-50 nm 77. Philip et al., Navin Jain et al., and Gerike et al., reported that diverse sizes and shapes of Au-NPs lies in the varying temperature of the extract 31, 78, 79. In this article documented that synthesis of AuNPs by edible mushroom Pleurotus florida. The synthesized gold nanoparticles from mushroom showed anticancer activity beside human chronic myelogenous leukemia (K562), human cervix (HeLa), human lung carcinoma (A-549) and human adenocarcinoma mammary gland (MDA-MA) under in-vitro conditions. Syed et al., Ahmad et al., and Bhat et al., reported that mostly the glucan content of mushroom was responsible for the stability of synthesized AuNPs 80, 81, 75. Borovaya et al., reported that synthesis of gold nanoparticles using T. cordifolia mushroom is demonstrated by this article 82. Some other typical gold nanoparticles produced by microorganisms are summarized in Table 2.
TABLE 2: MYCOSYNTHESIS OF GOLD NANOPARTICLES
Mushroom | Part used | Localization | Nanoparticle type | Size | Shapes | Reference |
Pleurotus ostreatus | Fruiting Body | Intracellular | Au | 22-39 nm | - | 27 |
Pleurotus florida | Fruiting Body | Polysaccharide/glucan | Au | 14.93±2.88 nm | Crystalline | 28 |
Pleurotus florida | Fruiting Body | Polysaccharide/glucan | Au | 12-15 nm | Crystalline | 26 |
Pleurotus florida | Fruiting Body | Extracellular | Au | 10-50 nm | Spherical | 26 |
Pleurotus florida | Fruiting Body | Extracellular | Au | 10-50 nm | Triangular | 26 |
Lentinus edodes | Fruiting Body | Intracellular | Au | 5-15 nm | Spherical | 29 |
Pleurotus ostreatus | Fruiting Body | Intracellular | Au | 5-15 nm | Spherical | 29 |
Grifola frondosa | Fruiting Body | Intracellular | Au | 5-15 nm | Spherical | 29 |
Ganoderma lucidum | Fruiting Body | Intracellular | Au | 5-15 nm | Spherical | 29 |
Pleurotus ostreatus | Fruiting Body | Intracellular | Au | 7.0±0.5 nm | Crystalline | 30 |
Volvariella volvacea | Fruiting Body | Extracellular | Au | 20-150 nm | Spherical | 16 |
Volvariella volvacea | Fruiting Body | Extracellular | Au | 20-150 nm | Triangular | 16 |
Volvariella volvacea | Fruiting Body | Extracellular | Au | 20-150 nm | Prism | 16 |
Volvariella volvacea | Fruiting Body | Extracellular | Au | 20-150 nm | Hexagonal | 16 |
Other Nanoparticles: Wong et al., Senapati et al., Wu et al., reported that synthesis of CdTe quantum dots by using fungi 32, 34, 83. Only two types of mushroom such as Coriolus versicolor and P. ostratus have been used to form CdS-NPs and were applied in the industrial field. Meng et al., reported that a solution of extracellular biomass of C. versicolor and cadmium sulfide was effectively used for the formation of NPs; Coriolus versicolor-CdS-NPs are 100-200 nm in size and have a spherical shape 84. Tiwari et al., reported that the species of P. ostratusit, Cd-NPs has been producing from intracellularly which have the size of 4-5 nm and spherical and used for diverse industrial applications 85.
Gupta et al., reported that Se-NPs from mushroom have spherical and moderately spherical shapes with the size of <50 nm using polysaccharide-protein complexes of mushrooms which is effortlessly aggregate and their anti-cancer activity is radically reduced by polysaccharide-protein complexes isolated from species of Pleurotus tuberregium 86. Kowalczyk et al., Brice-Profeta et al., reported that ZnS-NPs synthesized from mushroom showed sizes from 3 to 201 nm 87, 88. Faraji et al., reported that there are more than a few other metallic nanoparticles were synthesized using fungi such as mushrooms 89. There are numerous shapes of nanoparticles are synthesized from mushroom extract are summarized in Table 3.
TABLE 3: MYCOSYNTHESIS OF OTHER NANOPARTICLES
Mushroom | Part used | Localization | Nanoparticle type | Size | Shapes | Reference |
Pleurotus tuberregium | Fruiting Body | Polysaccharides protein | Se | - | - | 32 |
Pleurotus rhinoceros | Fruiting Body | Polysaccharides protein | Se | - | Spherical | 33 |
Agaricus bisporous | Fruiting Body | Extracellular | ZnS | 3-201 nm | Cubic | 34 |
Pleurotus ostreatus | Fruiting Body | Extracellular | ZnS | 2-5 nm | Spherical with crystalline | 35 |
Oriolus versicolor | Fruiting Body | Extracellular | CdS | 100-200 nm | Spherical | 36 |
Factors Affecting Mycosynthesis of Metal Nanoparticles: Baker et al., reported that there are numerous factors like pH of the solution, temperature, pressure, time, particle size, pore size, surroundings, concentration of the mushroom extracts used, concentration of the raw materials used and proximity greatly authority the quantity and quality of the synthesized nanoparticles and their categorization and applications 38. Ajayan et al., and Somorjai et al., reported that the scenery of the synthesized nanoparticles would be altered with the type of diverse adsorbate and the activity of the various catalysts used in the synthesis process 39, 40. Pennycook et al. reported that to accomplish monodispersity in solution phase of nanoparticles synthesis is challenged one. Some of them have reported the vibrant nature of the synthesized nanoparticles with different types of symptoms and implications by shifting with time, environment, shape and size of the particles and so forth 41. In the subsequent section, we have recapitulated some of the overriding factors that affect nanoparticle biosynthesis is listed in Table 4.
TABLE 4: EFFECTS OF VARIOUS FACTORS (pH, TEMPERATURE, AND CONTACT OR INCUBATION TIME) ON MYCOSYNTHESIS OF PRECIOUS METAL NANOPARTICLES
Factors | Shapes | Nanoparticles types | Reference |
pH | |||
1.6, 7, 12 | Crystalline | Au | 30 |
Temperature | |||
37 ºC | Spherical | Ag | 11 |
28 ± 1 ºC | Spherical | Ag | 19 |
27 ºC | Crystalline | Au | 28 |
37 ºC | Spherical | Au | 26 |
37 ºC | Triangular | Au | 26 |
25 ºC | Crystalline | Au | 30 |
Contact or incubation time | |||
24 h | Spherical | Ag | 11 |
72 h | Crystalline | Au | 26 |
72 h | Spherical | Au | 26 |
72 h | Triangular | Au | 26 |
Effect of Various Method or Technique: There are various methods for synthesizing nanoparticles, ranging from physical techniques using mechanical procedures to chemical or biological protocols using various organic and inorganic chemicals and living organisms. Pennycook et al., and Narayanan et al., reported that when to evaluate biological methods with other methods, which has additional benefits and low drawbacks. Then biological methods for nanoparticles synthesis are ecological and more adequate than established methods 41, 42.
Effect of pH: pH may play a crucial role in the biosynthesis of nanoparticles by green technology methods. Gardea-Torresdey et al., and Armendariz et al., reported that the pH of the solution medium influences the size and consistency of the synthesized nanoparticles 43, 44. Soni et al., reported that the shape and size of the particular nanoparticles are controlled by varying pH range of the solution 45. Dubey et al., reported that as diverse mushroom extracts and even the extracts imminent from different localization of the identical species of mushroom have different pH values, optimization of a synthetic etiquette is needed for the proficient synthesis of nanoparticles. It has been reported by several researchers that larger nanoparticles fashioned at lower pH compare to higher pH 46.
Effect of Temperature: Temperature is one more important parameter that affects the synthesis of nanoparticles using biological methods. When comparing biological method with physical and chemical methods, the synthesis of nanoparticles using green technology requires temperatures less than 100 ºC or ambient temperature. Because the temperature of the physical method requires utmost temperature (>350 ºC) and chemical methods require a temperature fewer than 350 ºC. Rai et al., reported that the scenery of nanoparticles would be indomitable by temperature of the reaction medium 47. Gericke et al. reported that gold nanoparticles fashioned with a superior rate at higher temperatures.
Nanorod- and platelet-shaped gold nanoparticles were synthesized at higher temperatures, while spherical-shaped nanoparticles produced at lower temperature 48. Andreescu et al., reported that the silver nanoparticles furthermore synthesized at higher temperatures 49. Some species of mushroom extract that with an enhance in temperature an increase in the sharpness of absorption peaks were found for both silver and gold nanoparticles. This is so because with an increase in temperature the rate of reaction also increased, which enhances the synthesis of nanoparticles. Fayaz et al., and Shaligram et al., reported that the sharpness in absorbance peak depends on the size of the synthesized nanoparticles, as with superior temperature 50, 51.
Effect of Pressure: Pressure is essential for the mycosynthesis of nanoparticles. Abhilash et al., reported that the shape and size of the biosynthesized nanoparticles would be exaggerated by pressure applied to the reaction medium 52. Tran et al., reported that the rate of diminution of metal ions using biological agents like mushroom extracts has been establishing to be much faster at ambient pressure conditions 53.
Effect of Incubation Time: Lots of research works also recommended that contact or incubation time also affects the mycosynthesis of nanoparticles. This is the period necessary for the achievement of all steps of the reaction. Darroudi et al., reported that the eminence and type of nanoparticles synthesized using green technology are deeply influenced by the length of time for which the reaction medium is incubated 54. Akbari et al., and Mudunkotuwa et al., reported that correspondingly the characteristics of the mycosynthesized nanoparticles were also altered with a time of incubation and greatly predisposed by the synthesis process, exposure to light, and storage conditions, and so forth 55, 56. Dubey et al., reported that an increase in contact time is accountable for the sharpening of the peaks in both silver and gold nanoparticles 46. Jayanta Kumar Patra et al., reported that long time storage of the mycosynthesized nanoparticles would be distress their shelf life and their probable 57.
Effect of Preparation Cost: The prospective application of nanoparticles in the emergent world uses, the costs associated with their synthesis need to be regulated and controlled. This is a very essential factor that influences nanoparticle synthesis. Yacaman et al., reported that when evaluating other methods of nanoparticle synthesis, mycosynthesis of nanoparticles involves less cost and can be performed on a hefty scale 58.
Effect of Particle Shape and Size: The size and shape of the nanoparticles play a significant role in formative their properties. Akbari et al., reported that the size of the nanoparticles would be affected by the melting point of nanoparticles 55. Baer et al., reported that diverse arrangement of nanoparticles has analogous energy which makes the conversion of their shape easy 59. Ruckenstein et al., reported that the chemical properties of nanoparticles would be affected by their dynamic scenery and shape 60.
Effect of Other Factors: Park et al., reported that the porosity of the mycosynthesized nanoparticles was influenced their quality and application 61. Various living systems such as mushrooms are wealthy in secondary metabolites that act as reducing and stabilizing agents for the myco-synthesis of nanoparticles. Haverkamp et al., reported that the composition of theses metabolites varies depending on the type of different mushroom species and the procedure used for its extraction 62. Mohanpuria et al., reported that different species of mushroom have distinctive intracellular and extracellular enzymes in unreliable quantities that affect nanoparticle synthesis 63. Baker et al. reported that the choice of purification methods of mycosynthesized nano-particles could persuade their quantity and quality 38.
FIG. 1: DIVERSE APPROACHES AND METHODS FOR SYNTHESIZING NANOPARTICLES 6, 7, 57
The Mechanism Behind Mycosynthesis: While various studies have been commenced on the screening and identification of mushroom species for controlled synthesis of noble metal nanoparticles, extremely little work has been performed to appreciate the genuine mechanism behind the synthesis of nanoparticles Fig. 2 64, 65, 66, 36. Pal Sovan Lal et al., reported that nanoparticles can be synthesized throughout two major methods, i.e., “top-down” and “bottom-up” approaches Fig. 1 67.
FIG. 2: MECHANISM OF NANOPARTICLE SYNTHESIS 64
Juhi Saxena et al., reported that the top-down approach principally works with a bulk form of material, and their nanoscale of size will be achieved by physical method of size reduction, e.g., thermal decomposition, laser ablation, mechanical milling, etching, lithography, and sputtering 68. Rai et al., reported that the bottom-up approach is comprehensively used for the preparation of nanoparticles, where involving a homogeneous system wherein catalysts like biological extracts (e.g., reducing agent and enzymes) synthesize nanostructure that are forbidden by catalyst properties, reaction media, and circumstances (e.g., solvents, stabilizers, and temperature) 69.
Gade et al., reported that the biological synthesis of nanoparticles is more favored than physical and chemical means because of hasty synthesis, better control over size and shape characteristics, cost-effectiveness, less toxicity and ecological approach 70. Role of fungi such as mushroom is effective nanofactories is communicable consideration from the researchers worldwide. Mycosynthesis of nanoparticles has been well predictable because this totipotent eukaryotic microorganism has numerous incredible features which have been well documented. Gade et al., reported that various species of mushroom restrain different types of enzyme-like extracellular, intracellular enzymes and polysaccharides, etc., so which can be used to synthesize diverse nanoparticle synthesis. There are various reasons mushroom can be elected as superior nano-factories over bacteria and plants 70. Kashyap et al. reported that mushroom produces huge amounts of extracellular enzymes which catalyze the heavy metal ions and produce nanoparticles. It can produce nanoparticle at an earlier rate than chemical synthesis 71.
Namita Soni et al. reported that mushroom could produce nanoparticle extracellularly which is very appropriate for easier downstream processing and handling of biomass 72. Mushroom can produce nanoparticles together extracellularly as well as intracellularly. The accurate mechanism of mushroom is not understood entirely. Aromal et al., reported that putative mechanisms throughout intracellular synthesis comprise heavy metal binding to mushroom’s mycelia cell wall by proteins or enzymes present on it via electrostatic interactions. Moreover, the metal ions are reduced by enzymes present in the cell wall. This leads to aggregation of metal ions and configuration of nanoparticles 73. The different size, shape, and types of nanoparticles will be fashioned by different species of mushroom, which is mentioned in Table 1, 2 and 3.
TABLE 5: APPLICATION OF NANOPARTICLES
Type of nanoparticle | Application | Reference |
Ag | Antimicrobial activity | 12 |
Au | Anti-cancer activity,
catalytic activity |
37 |
CdS | Semiconductor quantum dots | 36 |
Se | Cellular uptake, antiproliferative activity, anticancer activity | 32 |
Fe | - | 23 |
Pd | - | 23 |
ZnS | Selenite uptake rate,
nano tunned devixe |
34 |
Chitosan | Antioxidant activity | 23 |
CONCLUSION: This review has summarized the topical research work in the field of mycosynthesis of novel metal nanoparticles and perilously discusses the various mechanisms planned behind it. Owing to the wealthy biodiversity of mushroom species; their potential for the synthesis of novel metal nanoparticles is nevertheless to be fully explored. Enormous numbers of mushroom species are presented in nature, and many of them can be exceptional candidates for nanoparticle synthesis. Clarification of the mechanism behind mycosynthesis of valuable metal nanoparticles is necessary to develop a coherent approach.
A thorough understanding of biochemical mechanisms complicated in the fungi-mediated nanoparticle synthesis is a prerequisite to make this approach reasonably competitive with the conventional methods. Mycosynthesis of metallic nanoparticles (viz., Ag-NP, Au-NP, Se-NP, CdS-NP, Fe-NP, Pa-NP, and ZnS-NP) using mushrooms by different routes, and tested for 79% of biomedical and 21% of industrial applications. Mushroom metal-NPs were investigated for industrial applications such as for inorganic NPs, carbon nanotubes and treatment of waste as nano-biosorbents for adsorption of toxic metals for clearout our environment using ecological natural material and reducing environmental pollution in the future.
ACKNOWLEDGEMENT: The authors acknowledge the Vivekanandha College of Engineering for Women, Tiruchengode, Namakkal (Dt), India for providing financial assistance.
CONFLICT OF INTEREST: The authors declare that they have no conflict of interest.
REFERENCES:
- Haq MU, Rathod V, Singh D, Singh AK, Ninganagouda S, and Hiremath J: Dried mushroom Agaricus bisporus mediated synthesis of silver nanoparticles from Bandipora District (Jammu and Kashmir) and their efficacy against methicillin-resistant Staphylococcus aureus (MRSA) Strains. Int J Nanosci 2015; 5: 1-8.
- Sujatha S, Tamilselvi, Subha K and Panneerselvam A: Studies on the biosynthesis of silver nanoparticles using mushroom and its antibacterial activities. Int J Curr Microbiol Appl Sci 2013; 2: 605-14.
- Sanghi R and Verma P: Biomimetic synthesis and characterization of protein capped silver nanoparticles. Bioresour Technol 2009; 100: 501-04.
- Bernardshaw S, Johnson E and Hetland G: An extract of the mushroom Agaricus Blazei Murill administered orally protects against systemic Streptococcus, Pneumonia infection in mice. Scand J Immunol 2005; 62: 393-98.
- Mukherjee P, Ahmad A, Senapati S, Sainkar SR, Khan MI, Pasricha R, Ajaykumar PV, Alam M, Kumar R, and Sastry M: Fungus-mediated synthesis of silver nanoparticles and their immobilization in the mycelial matrix: A novel biological approach to nanoparticle synthesis. Nano Lett 2001; 1: 515-19.
- Nadagouda MN and Varma RS: Green synthesis of silver and palladium nanoparticles at room temperature using coffee and tea extract. Green Chem 2008; 10: 859-62.
- Sathishkumar M, Krishnamurthy S and Yun YS: Immobilization of silver nanoparticles synthesized using the longa tuber powder extract on cotton cloth for bactericidal activity. Biol Res Technol 2010; 101: 7958-65.
- Huang J, Li Q, Sun D, Lu Y, Su Y, Yang X, Wang H, Wang Y, Shao W, He N, Hong J and Chen C: Biosynthesis of silver and gold nanoparticles by novel sundried camphora leaf. Nanotechnology 2007; 18: 1-11.
- Maurya S, Bhardwaj AK, Gupta KK, Agarwal S, Kushwaha A, Chturvedi VK, Pathak RK, Gopal R, Uttam KN, Singh AK, Verma V and Singh MP: Green synthesis of silver nanoparticles using Pleurotus and its bactericidal activity. J Cell Mol Biol 2016; 62: 1-3.
- Owaid MN, Al-Saeedi SS and Abed IA: Study on UV-Visible for detection of biosynthesis of silver nanoparticles by Oyster mushroom’s extract. J Water Environ Nano-technol 2017; 2: 66-70.
- Sudhakar T, Nanda A, Babu SG, Janani S, Evans MD and Markose TK: Synthesis of silver nanopartcles from edible mushroom and its antimicrobial activity against human pathogen. Int J Pharmtech Res 2014; 6: 1718-23.
- Mirunalini S, Arulmozi V, Deepalakshmi K and Krishnaveni M: Intracellular biosynthesis and antibacterial activity of silver nanoparticles using edible mushroom. Not Sci Biol 2012; 4: 55-61.
- Dhanasekaran D, Latha S, Saha S, Thajuddin N and Panneerselvam A: Extracellular biosynthesis, characterization and in-vitro antibacterial potential of silver nano-particles using Agaricus bisporus. J Exp Nanosci 2013; 8: 579-88.
- Haq MU, Rathod V, Shivraj N, Singh D, Yasin M and Singh AK: Silver nanoparticles from mushroom Agricus bisporus and their activity against multi-drug resistant strains of Klebsiella sp., Pseudomonas sp. & Acinetobacter sp. Int J Nat Prod Res 2015; 5: 20-26.
- Sanghi R and Verma P: Biomimetic synthesis and characterization of protein capped silver nanoparticle. Biol Res Technol 2009; 100: 501-04.
- Philip D: Biosynthesis of Au, Ag and Au-Ag nanoparticles using edible mushroom extract. Spectrochim Acta A Mol Bimol Spectrosc 2009; 73: 374-81.
- Balahanmuga P, Santhosh S, Giyaullah H, Balakumaran MD & Kalaichelvan PT: Mycosynthesis, characterisation and antibacterial activity of silver nanoparticles from Microsporus xanthopus: A macro mushroom. Int J Innov Res Sci Eng Technol 2013; 2: 6262-70.
- Muthu N and Shanmugasundaram K: Comparative study of phytochemicals in aqueous and silver nanoparticles extracts of Acrocybe aegerita, (V.BRIG.) singer black poplar mushroom. Int J Pharma Bio Sci 2015; 6: 190-197.
- Deepak K, Rahi and Barwal M: Biosynthesis of silver nanoparticles by their antibacterial and antibiotic activity enhancing potential. World J Pharm Pharm Sci 2015; 4: 1234-47.
- Karwa A, Gaikwar S and Rai M: Mycosynthesis of silver nanoparticles using Lingzhi or Reishi medicinal mushroom, Ganoderma lucidum (W. Curt.:Fr.) P. Karst. and their role as antimicrobials and antibiotic activity enhancers. Int J Med Mushroom 2011; 13: 483-91.
- Gurunathan S, Raman J, Malek SN, Ajohn P and Vikineswary S: Green synthesis of silver nanoparticles using Ganoderma Neo-Japonicumimazeki: A potential cytotoxic agent against breast cancer cells. Int J Nanomed 2013; 8: 4399-13.
- Bhat R, Deshpande R, Ganachari SV, Huh DS and Venkataraman A: Photo-irradiated biosynthesis of silver nanoparticles using edible mushroom Pleurotus florida and their antibacterial activity studies. Bioinorg Chem Appl 2011; 2011: 1-7.
- Owaida MN, Raman J, Lakshmanan H, Al-Saeedi SS, Sabaratnam V and Ali Abe I: Mycosynthesis of silver nanoparticles from Pleurotus corncopiaevar. Citrino-pileatus and its inhibitory effect against Candida sp. Adv Mater Lett 2015; 153: 186-90.
- Anthony KJ, Murugan M, Jeyaraj M, Rathinam NK and Sangiliyandi G: Synthesis of silver nanoparticles using pine mushroom extract: A potential antimicrobial agent against coli & B. subtilis. J Ind Eng Chem 2013; 5: 1-7.
- Arun G, Eyini M and Gunasekaran P: Green synthesis of silver nanoparticles using the mushroom fungus Schizophyllum commune and its biomedical applications. Biotechnol. Bioprocess Eng 2014; 19: 1083-90.
- Bhat R, Deshpande R, Ganachari SV, SungHuh D and Venkataraman: Photo-bio-synthesis of irregular shaped functionalized gold nanoparticles using edible mushroom Pleurotus florida and its anticancer evaluation. J Photochem Photobiol B Biol 2013; 125: 63-69.
- Ahmad A, Mukherjee P, Senapati S, Mandal D, Khan MI, Kumar R and Sastry M: Extracellular biosynthesis of silver nanoparticles using the fungus Fusarium oxysporum. Colloids Surf B Biointerfaces 2003; 28: 313-18.
- Sen IK, Maity K and Islam SS: Green synthesis of gold nanoparticles using a glugan of an edible mushroom and study of catalytic activity. Carbohydr Polyme 2013; 91: 518-28.
- Vetchinkina EP, Loshchinina EA, Vodolazov IR, Kursky VF, Dykman LA and Nikitina VE: Biosynthesis of nanoparticles of metals and metalloids by Basidiomycetes. Preparation of gold nanoparticles by using purified fungal phenol oxidases. Appl Microb Biotechnol 2016; 5: 76-80.
- Politi J, Stefano LD, Longobardi S, Giardinad P, Rea I, Methiviera C, Pradier CM, Casale S and Spadavecchia J: The amphiphilic hydrophobin Vmh2 plays a key role in one step synthesis of hybrid protein-gold nanoparticles. Colloids Surf B Biointerfaces 2015; 136: 214-21.
- Phili D: Green synthesis of gold and silver nanoparticles using rosa sinensis. Physica E 2010; 42: 1417-24.
- Wong K: Preparation of highly stable selenium nano-particles with strong anti-tumor activity using tiger milk mushroom. Innovation and Technology Development Office www.polyu.edu.hk/ITDO. 2014.
- Wu H, Zhu H, Li X, Liu Z, Zheng W and Chen T: Induction of apoptosis and cell cycle arrest in A549 human lung adenocarci-noma cells by surface- capping selenium nanoparticles: an effect enhance by a polysaccharide-protein complex from Polyporus rhinocerus. J Agric Food Chem 2013; 61: 1-30.
- Senapati US, Jha DK, Sarkar D and Res J: Structural, optical, thermal and electrical properties of fungus guided biosynthesized zinc sulphide nanoparticles. Res J Chem Sci 2015; 5: 33-40.
- Senapati US and Sarkar D: Characterization of bio-synthesized zinc sulphide nanoparticles using edible mushroom ostreatus. Indian J Phys 2014; 88: 557-62.
- Chowdhury S, Basu A and Kundu S: Green synthesis of protein capped silver nanoparticles from phytopathogenic fungus Macrophomina phaseolina (Tassi) gold with antimicrobial properties against multidrug-resistant bacteria. Nanoscale Res. Lett 2014; 9: 2-11.
- El-Batal AI, Elkenawy NM, Yassin AS and Amin MA: Laccase production by Pleurotus ostreatus and its application in the synthesis of gold nanoparticles. Appl Biotechnol Rep 2015; 5: 31-39.
- Baker S, Rakshith D, Kavitha KS, Santosh P, Kavitha HU, Rao Y and Satish S: Plants: Emerging as nanofactories towards facile route in the synthesis of nanoparticles. Bio Impacts 2013; 3: 111-17.
- Ajayan PM: Nanotechnology: How does a nanofibre grow? Nature 2004; 427: 402-03.
- Somorjai GA and Park JK: Colloid science of metal nanoparticle catalysts in 2D and 3D structures. Challenges of nucleation, growth, composition, particle shape, size control and their influence on activity and selectivity. Top Catal 2008; 49: 126-35.
- Pennycook TJ, McBride JR, Rosenthal SJ, Pennycook SJ, and Pantelides ST: Dynamic fluctuation in ultrasmall nanocrystals include white light emission. Int Nano Lett 2012; 12: 3038-42.
- Narayanan KB and Sakthivel N: Green synthesis of biogenic metal nanoparticles by terrestrial and aquatic phototrophic and heterotrophic eukaryotes and biocompatible agents. Adv Colloid Interface Sci 2011; 169: 59-79.
- Gardea-Torresdey JL, Tiemann KJ, Gamez G, Dokken K and Pingitore NE: Recovery of gold (III) by Alfalfa biomass and binding characterization using X-ray Micro-fluorescence. Adv Environ Res 1999; 3: 83-93.
- Armendariz V, Herrera I and Peralta-Videa JR: Size-controlled gold nanoparticle formation by Avena sativa Biomass: Use of plants in nanobiotechnology. J Nanopart Res 2004; 6: 377-82.
- Soni N and Prakash S: Factors affecting the geometry of silver nanoparticles synthesis in tropicum and F. oxusporum. American J Nanotechnol 2011; 2: 112-21.
- Dubey SP, Lahtinen M and Sillanpaa M: Tansy fruit mediated greener synthesis of silver and gold nanoparticles. Process Biochem 2010; 45: 1065-71.
- Rai A, Singh A, Ahmad A and Sastry M: Role of halide ions and temperature on the morphology of biologically synthesized gold nanoparticles. Langmuir 2006; 22: 736-41.
- Gericke M and Pinches A: Biological synthesis of metal nanoparticles. Hydrometallurgy 2006; 83: 132-40.
- Andreescu D, Eastman C, Balantrapu K and Goia DV: Simple route for manufacturing highly dispersed silver nanoparticles. J Mater Res 2007; 22: 2488-96.
- Fayaz AM, Balaji K, Kalaichelvan PT and Venkatesan R: Fungal based synthesis of silver nanoparticles-an effect of temperature on the size of particles. Colloids Surf B Biointerfaces 2009; 74: 123-26.
- Shaligram NS, Bule M, Bhambure R, Singhal RS, Singh SK, Szakacs G and Pandey A: Biosynthesis of silver nano-particles using an aqueous extract from the compactin producing fungal strain. Process Bioch 2009; 44: 939-43.
- Abhilash and Pandey BD: Synthesis of zinc-based nanomaterials: a biological perspective. IET Nano-biotechnol 2012; 6: 144-48.
- Tran QH, Nguyen VQ and Le AT: Silver nanoparticles: synthesis, properties, toxicology, applications and pers-pectives. Adv Nat Sci Nanosci Nanotech 2013; 4: 1-20.
- Darroudi M, Ahmad MB, Zamiri R, Zak AK, Abdullah AH and Ibrahim NA: Time-dependent effect in green synthesis of silver nanoparticles. Int J Nanomed 2011; 6: 677-81.
- Akbari B, Tavandashti MP and Zandrahimi M: Particle Size characterization of nanoparticles- a practical approach. Iran J Mat Sci Eng 2011; 8: 48-56.
- Mudunkotuwa A, Pettibone JM and Grassian VH: Environmental implications of nanoparticle aging in the processing and fate of copper-based nanomaterials. Environ Sci Technol 2012; 46: 7001-10.
- Patra JK and Baek KH: Green Nanobiotechnology: Factors Affecting Synthesis and Characterization Techniques. J Nanomater 2014; 20: 1-12.
- Yacaman MJ, Ascencio JA, Liu HB, and Gardea-Torresdey J: Structure shape and stability of nanometric sized particles. J Vac Sci Technol B 2001; 19: 1091-03.
- Baer DR, Engelhard MH and Johnson GE: Surface characterization of nanomaterials and nanoparticles: Important needs and challenging opportunities. J Vac Sci Technol A 2013; 31: 050820-34.
- Ruckenstein E and Kong XZ: Control of pore generation and pore size in nanoparticles of poly (Styrene-Methyl Methacrylate- Acrylic acid). J Appl Polym Sci 1999; 72: 419-26.
- Park Y, Hong YN, Weyers A, Kim YS and Linhatdt RJ: Polysaccharides and phytochemicals: A natural reservoir for the green synthesis of gold and silver nanoparticles. IET Nanobiotechnol 2011; 5: 69-78.
- Haverkamp RG, Marshall AT and Van Agterveld D: Your carats: Nanoparticles of gold-silver-copper alloy produced in-vivo. J Nanopart Res 2007; 9: 697-00.
- Mohanpuria P, Rana NK and Yadav SK: Biosynthesis of Nanoparticles: Technological concepts and future app-lications. J Nanopart Res 2008; 10: 507-17.
- Elavazhagan T and Arunachalam KD: Memecylon edule leaf extract mediated green synthesis of silver and gold nanoparticles. Int J Nanomed 2011; 6: 1265-78.
- Mehrdad F and Farhadi K: Biological and green synthesis of Ag nanoparticles. Tur J Eng Env Sci 2010; 34: 281-287.
- Aboul El-Nour KM, AA Eftaiha, Al-Warthan A and Ammar RA: Synthesis and application of silver nano-particles. ARAB J Chem 2010; 3: 135-40.
- Pal PL, Jana U, Manna PK, Mohanta GP and Manavalan RM: Nanoparticle: an overview of preparation and characterization. J Appl Pharm Sci 2011; 1: 228-34.
- Saxenaa BJ, Sharma MM, Guptab S and Singh A: Emerging role of fungi in nanoparticle synthesis and their applications. World J Pharm Pharm Sci 2014; 3: 1586-13.
- Rai M, Yadav A and Bridge P and Gade A: Myconano-technology: A new and emerging science. Appl Mycol 2009; 6: 258-67.
- Gade A, Bonde PP, Ingle AP, Marcato P, Duran N and Rai MK: Exploitation of Aspergillus for synthesis of Ag nano-particles. J Biobased Mater Bioenergy 2008; 2: 243-47.
- Kashyap PL, Kumar S, Srivastava AK and Sharma AK: Myconanotechnology in agriculture: a perspective. World J Microbiol Biotechnol 2012; 29: 191-07.
- Soni N and Prakash S: Factors affecting the geometry of silver nanoparticles synthesis in tropicum and F. oxysporum. American J Nanotechnol 2011; 2: 112-21.
- Aromal SA and Philip D: Green synthesis of gold nanoparticles using Trigonella foenum-graceum and its size- dependent catalytic activity. Spectrochim Acta A Mol Biomol Spectrosc 2012; 97: 1-5.
- Narayanan KB, Park HH and Han SS: Synthesis and characterization of biomatrixed-gold nanoparticles by the mushroom Flammulina velutipes and its heterogeneous catalytic potential. Chemosphere 2015; 141: 169-75.
- Bhat R, Sharanabasava VG, Deshpande R, Shetti UI, Sanjeev G and Venkataraman A: Photo-bio-synthesis of irregular shaped functionalized gold nanoparticles using edible mushroom florida and its anticancer evaluation. J Photochem Photobiol B Biol 2013; 125: 63-69.
- Zhang X, He X, Wang K, Wang Y, Li H and Tan W: Biosynthesis of size-controlled gold nanoparticles using fungus Penicillium sp. Int J Nanosc Nanotech 2009; 9: 5738-44.
- Sen IK, Maity K and Islam SS: Green synthesis of gold nanoparticles using a glucan of an edible mushroom and study of catalytic activity. Carbohydr Polym 2013; 91: 518-28.
- Jain N, Bhargava A, Majumdar S, Tarafdar JC and Panwar J: Extracellular biosynthesis and characterization of silver nanoparticles using Aspergillus flavus NJP08: A mechanism perspective. RSC Adv 2011; 3: 635-41.
- Gerike M and Pinches A: Biological synthesis of metal nanoparticles. Hydrometallurgy 2006; 83: 132-40.
- Syed A and Ahmad A: Extracellular biosynthesis of CdTe quantum dots by the fungus oxysporum and their antibacterial activity. Spectrochim Acta A Mol Biomol Spectrosc 2013; 106: 41-47.
- Ahmad A, Mukherjee P, Mandal D, Senapati S, Khan R and Sastry M: Enzyme mediated extracellular synthesis of CdS nanoparticles by the fungus oxysporum. J ACS 2002; 124: 12108-09.
- Borovaya M, Pirko Y, Krupodorova T, Naumenko A, Blume Y and Yemets A: Biosynthesis of cadmium sulphide quandum dots by using ostreatus (Jacq)p. Kumm Biotechnol Biotechnol Equip 2015; 29: 1-8.
- Wu HF, Kailasa SK and Shastri L: Electrostatically self-assembled azides on zinc sulfide nanoparticles as multifunctional nanoprobes for peptide and protein analysis in MALDI-TOF MS. Talanta 2010; 82: 540-47.
- Meng X, Zhou QL, Wu JP and Yang LR: Highly efficient solvent-free synthesis of v1, 3-diacylglycerols by lipase immobilized on nano-sized magnetite particles. Food Chem 2014; 143: 319-24.
- Tiwari DK, Behari J and Sen P: Time and dose-dependent antimicrobial potential of Ag nanoparticles synthesized by a top-down approach. Curr Sci 2008; 95: 647-55.
- Gupta V, Gupta AR and Kant V: Synthesis, characterization and biomedical application of nanoparticles. Sci Int 2013; 1: 167-74.
- Kowalczyk B, Lagzi I and Grzybowski BA: Nano-separations: Strategies for size and shape-selective purification of nanoparticles. Curr Opin Colloid. Interface Sci 2011; 16: 135-48.
- Brice-Profeta S, Arrio MA and Tronc E: Magnetic Order in gama-Fe2o3 Nanoparticles: a XMCD Study. J Magn Magn Mater 2005; 288: 354-65.
- Faraji M, Yamini Y and Rezaee M: Magnetic nano-particles: Synthesis, stabilization, functionalization, chara-cterization and applications. J Iran Che Soc 2010; 7: 1-37.
How to cite this article:
Prabhu N, Karunakaran S, Devi SK, Ravya R, Subashree P and Vadivu MS: Biogenic synthesis of myconanoparticles from mushroom extracts and its medical applications: A review. Int J Pharm Sci & Res 2019; 10(5): 2108-18. doi: 10.13040/IJPSR.0975-8232.10(5).2108-18.
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Article Information
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2108-2118
706
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English
IJPSR
N. Prabhu *, S. Karunakaran, S. K. Devi, R. Ravya, P. Subashree and M. S. Vadivu
Department of Biotechnology, Vivekanandha College of Engineering for Women, Elayampalayam, Tiruchengode, Tamil Nadu, India.
prabhu.aut.26@gmail.com
10 August 2018
29 October 2018
31 October 2018
10.13040/IJPSR.0975-8232.10(5).2108-18
01 May 2019