BIOLOGICALLY ACTIVE COMPOUNDS FROM LEUCAS LAVANDULAEFOLIA
AbstractThe investigation of terrestrial plants origin aimed at searching new natural biologically active compounds is a central issue of this kind of studies, through structure elucidation combined with biological tests. We investigated the biologically active secondary metabolites from Leucas lavandulaefolia towards various effects on the behavior of Aphanomyces cochlioides zoospores and with antimicrobial activity. We purified the following compounds acacetin, chrysoeriol, luteolin, acacetin 7-O-β-D-glucuronide, acetoside, isoacetoside, salicylic acid and caffeic acid. Their structures were elucidated by spectroscopic analyses and compared with those of the reported data. Five compounds (luteolin, acacetin 7-O-β-D-glucuronide, acetoside, isoacetoside, and salicylic acid) were isolated from L. lavandulaefolia for the first time ever. It was found that luteolin showed a strong attractant and encystment activity toward zoospores of the phytopathogenic fungus A. cochlioides zoospores. Chrysoeriol also showed an attractant activity towards A. cochlioides zoospores. This is the first research report of L. lavandulaefolia regarding zoospores bioassay. Antibacterial assay on these compounds indicated that they have antimicrobial activity against the tested bacteria Bacillus subtilis and Staphylococcus aureus. Some of the identified secondary metabolites provided the evidence for the traditional usage of the plants as different therapeutic potentials (anti-inflammatory, antitussive and anti-diabetes) and may be useful for developing an effective control strategy to contest.
Article Information
8
1013-1021
627
2238
English
Ijpsr
Parvin Begum *, Yanqing Wang and Bunshi Fugetsu
Laboratory of Environmental Medical Chemistry, Graduate School of Environmental Science, Hokkaido University, Sapporo 060-0810, Japan
parvinchy@ees.hokudai.ac.jp
21 July, 2014
29 September, 2014
01 December, 2014
http://dx.doi.org/10.13040/IJPSR.0975-8232.6(3).1013-21
01 March, 2015