BOILED MILK INDUCED PYREXIA IN RABBITS- ANTIPYRETIC ACTIVITY VERNONIA CINEREA ROOTSAbstract
Antipyretic effect of petroleum ether and chloroform soluble fractions of ethanol extract of the roots of Vernonia cinerea was investigated. Intraperitoneal administration of boiled milk at a dose 0.5 ml/kg body weight in albino rabbit leads to pyrexia. Intraperitoneal (i.p. route) administration of petroleum ether and chloroform soluble fractions of ethanol extract of the roots of Vernonia cinerea at a dose 250 mg/kg body weight were shown significantly reduce the elevated body temperature of rabbit which was compared with standard aspirin (market product) and solvent used.
R Sankar Anand*, V Subhadra Devi, B Arunprasath, A Subageetha and C H Anusha
Department of Pharmacology, Jagans college of Pharmacy, Nellore, Tamilnadu, India
23 August, 2010
22 November, 2010
24 December, 2010