CAPSAICIN (C18H27NO3) AND PHYTOL (C20H40O) FROM CAPSICUM ANNUM L. LEAF DOCKED AGAINST SALIVARY GLAND PROTEIN OF CULEX QUINQUEFASCIATUS

Overpopulation leads to rapid urbanization, and industrialization has directed an unplanned town expansion with no sanitary facilities and proper wastewater disposal arrangements drains in the pond. Mosquitoes create a significant public health problem in India and serve as vectors for transmitting various diseases like malaria, filariasis, dengue, chikungunya, etc., to humans. This results in the creation of water bodies which are highly conducive for the breeding of mosquitoes. The study revealed the biological activity of the compounds Capsaicin (C₁₈H₂₇NO₃), and Phytol (C₂₀H₄₀O) from Capsicum annum L. docked against salivary gland protein (PMDBID PM 0079099). The Pharmacophore model development and 3D QSAR analysis of the selected compounds were carried out using the Pharmacophore alignment scoring engine (PHASE) module of Schrodinger. The 3D structures of proteins are of vital importance in providing insights into their molecular functions. The glide score of the compound Capsaicin was -2.63 and 2 two number of H-bond interactions with the distance of 2.298 and 1.485 and Phytol was -1.46 and one number of H-bond with a distance of 1.900. Docking results showed that compounds, Capsaicin, and Phytol actively on the target protein, and it can be used as a candidate in vector control. Hence, the present study on vector control has explored by in-silco molecular docking study between compounds of Capsaicin and Phytol with salivary gland protein of Culex quinquefasciatus.