CARDIOPROTECTIVE EFFECT OF MORUS ALBA L. LEAVES IN ISOPRENALINE INDUCED RATSAbstract
The study was designed to evaluate the cardioprotective effect of methanolic extract of Morus alba L. leaves against isoprenaline- induced myocardial infarction and was investigated by an in vivo method in rats. Male Wistar albino rats were divided into four groups (n=6). Group I rats served as normal control. Group II rats served as isoprenaline induced toxic control (110 mg/kg body weight) which was injected intraperitoneally (i.p.) for two consecutive days (14th and 15th days). Group III rats were given Morus alba intragastric intubation (500 mg/kg body weight) for 15 days. Group IV rats were also given Morus alba as in Group III and additionally isoprenaline was given for two consecutive days (14th and 15th days).The results described the cardioprotective effect that was observed in Group IV which showed a significant (P< 0.05) decreased levels of TBARS and enhanced the activities of both enzymatic and non-enzymatic antioxidants (SOD, CAT, GPx and GSH) in myocardial infarcted rats when compared to Groups II and III. In serum, the biomarkers (LDH, CK) activities were significantly (P< 0.05) increased in Group II compared to pretreated Group IV. Histopathological studies were also co-relating with the above biochemical parameters. These findings concluded the cardioprotective effect of Morus alba on lipid peroxidation and antioxidant defense system during isoprenaline -induced myocardial infarction in rats.
S. Madhumitha and A. Indhuleka*
Assistant Professor, PG & Research Department of Biotechnology, Kongunadu Arts & Science College, Coimbatore-641029, Tamil Nadu, India
26 January, 2012
27 March, 2012
28 April, 2012
01 May, 2012