CELL PROLIFERATIVE ACTION OF HYDROALCOHOLIC EXTRACT OF TRIGONELLA FOENUM GRAECUM IN RATS
AbstractThe healing of an adult skin wound is a complex process of different tissues and cell lineages. Understanding wound healing involves understanding of inflammation, proliferation, and maturation phase. The present study was aimed at evaluation of proliferative action of hydroalcoholic extract of Trigonella foenum graecum (HETG) in albino rats using excision and incision wound model. HETG 5% W/W and HETG 10% W/W in simple ointment base were used and Povidone iodine 5%w/w was used as standard. The experimental animals were topically applied with test and standard twice daily for consecutive 14 days. Proliferative activity was studied in excision wound model and incision wound model. The parameters studied are rate of wound contraction and period of epithelisation in excision wound model. Tensile strength and hydroxyproline content in the scab was studied in incision wound model. Histopathological studies were performed. Based on the results HETG 10% W/W shown significant cell proliferative activity in granulation, contraction and epithelialisation of proliferation phase
Article Information
28
708-13
335
1193
English
IJPSR
P. Muralidharan*, M. Thenmozhi and R. Prakash
Department of Pharmacology, C. L. Baid Metha College of Pharmacy, Thoraipakkam, Chennai, Tamilnadu, India
pmuralidaran@hotmail.com
27 August, 2015
30 September, 2015
05 December, 2015
10.13040/IJPSR.0975-8232.7(2).708-13
01 February, 2016
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