CHARACTERIZATION OF FRUCTOSE DIET INDUCED DIABETES MELLITUS IN SWISS ALBINO MICE

Diabetes mellitus is an endocrine disorder, in which a person has high blood sugar, and the body does not produce sufficient insulin, or cells do not act in response to the insulin that is produced. Diabetes mellitus is a complicated metabolic disease that has gravely affected the human health and quality of life. As increase in carbohydrate intake, especially of fructose and high rich diet are both factors that contribute to the development of diabetes mellitus. In the present study, the characterization of fructose diet induced diabetes mellitus in Swiss albino mice was studied. Animals were divided into two groups, group A (Control) and group B (Fed with fructose diet). Oral administration of 10% fructose solution to Swiss albino mice for 10 weeks resulted in diabetes mellitus. For the duration of the experiment bodyweight, fasting blood glucose level and biochemical parameters (total cholesterol, total serum protein, serum creatinine and blood urea) were measured. The study revealed that fructose diet resulted in significant increase in bodyweight, fasting blood glucose level, total cholesterol, creatinine and blood urea. However, total serum protein in fructose fed mice group decreased significantly as compared to control. It is concluded from the experimental study that fructose diet increase glucose level, biochemical parameters and cause diabetic in Swiss albino mice