CHEMICO-BIOLOGICAL EFFECTS OF MONASCUS FERMENTED RICE (ANGKAK) IN HYPERLIPIDEMIC RATS: A COMPARATIVE ANALYSIS
AbstractAngkak rice (red mold rice, red yeast rice, Chinese red rice) which is a product of solid fermentation was prepared from non glutinous rice (Oryza sativa L.). Five different angkak samples containing varied level of lovastatin, pravastatin and citrinin suspension at a dose of 1g/kg were administered to hyperlipidemic rats for 30 days. There was a significant decrease in serum total cholesterol (30.8%), total triglyceride (33.3%), high-density and low-density lipoprotein cholesterol (25.9% and 40.5% respectively) in angkak fed hyperlipidemic rats in comparison to untreated hyperlipidemic rats (p<0.05). No significant difference in serum total cholesterol, total triglyceride, high-density lipoprotein and low-density lipoprotein cholesterol in serum of hyperlipidemic rats treated with angkak 1 (lovastatin 3.410 mg/g, pravastatin 1.524 mg/g and citrinin 8.345 mg/g) and angkak 4 (lovastatin 3.331 mg/g, pravastatin 1.751 mg/g and citrinin 9.874 mg/g) in comparison to hyperlipidemic rats treated with standard lovastatin (10 mg/kg) was observed. Animals fed with angkak samples showed no significant difference in their serum creatinine kinase, serum creatinine level and liver enzymes in comparison to normal control rats.
Article Information
45
2616-25
616
1070
English
Ijpsr
Mojeer Hasan, Prakash Chandra Bhatt and Bibhu Prasad Panda*
Microbial and Pharmaceutical Biotechnology Laboratory, Centre for Advanced Research in Pharmaceutical Science, Faculty of Pharmacy, Jamia Hamdard, New Delhi, India
bibhu_panda31@rediffmail.com
31 October, 2014
23 December, 2014
14 May, 2015
10.13040/IJPSR.0975-8232.6(6).2616-25
01 June, 2015
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