CHRONIC TOXICITY STUDIES OF PLUMERIA ACUMINATA AND GALEGA PURPUREA IN EXPERIMENTAL ANIMALS
AbstractThe use of medicinal plants and preparations derived from them as dietary supplements, nutraceuticals, functional foods and herbal medicinal products has become more widely accepted in developing countries. Therefore, it is important to evaluate the adverse effects of these plants and their preparations. The objective of this study was to evaluate the safety of the methanol extracts Plumeria acuminata (MEPA) and Galega purpurea (MEGP) by single the long-term oral administration in mice. The study of chronic toxicity was determined by oral feeding male mice daily with the MEPA and MEGP at the dose of 300, 600 and 1,200 mg/kg body weight continuously for 270 days. The results of chronic toxicity showed no abnormalities in the test groups as compared to the controls. Hematological and blood chemical values in treated groups were normal in comparison with the control group. Non-toxicity effect of MEPA and MEGP were present as no changes in body weight, internal organ weight, and general behaviors. Macroscopic or microscopic of internal organs or tissues in treated rats showed no changes. Therefore, the methanol extract of MEPA and MEGP given orally to male mice did not produce both acute and chronic toxicities
Article Information
30
2105-2112
646KB
1363
English
IJPSR
Periyasamy Gomathi*, Malaya Gupta and Upal Kanti Mazumder 2
M. Pharm., Ph. D, Associate Professor, Vaagdevi College of Pharmacy, Kishanpura, Hanumkonda, Warangal- 506 001, Andhra Pradesh, India
04 March, 2012
14 May, 2012
23 June, 2012
http://dx.doi.org/10.13040/IJPSR.0975-8232.3(7).2105-12
01 July 2012
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