CLINICAL STUDY ON THE IMMUNOMODULATORY EFFECT OF NIDIGDHIKADILEHA ON PRANAVAHA SROTO DUSHTI W. S. R. UPPER RESPIRATORY TRACT INFECTIONS IN CHILDREN

Aim of study: A Randomized controlled trial was planned to evaluate the Clinical efficacy of Nidigdhikadileha an Ayurveda multi-dimensional herb preparation in children suffering from Recurrent Respiratory tract infection in children. Nidigdhikadileha contains Nidigdhika (Solanum Xanthocarpum), Pippali (Piper longum), Amrita (Tinospora cardifolia), and Nagar (Zingiber officinale). All these drugs have been described to have anti-tussive and antimicrobial properties. Material & methods: A total of 90 children, including male and female children, were studied for complaining of Recurrent Upper Respiratory Tract infections and were registered and divided into 3 groups (Group A, B, C). In group A, children were administered Nidigdhikadileha, dose180-200 mg/kg/dose twice a day for 2 months in children suffering from RURTI. In group B, honey drops were administered to 30 children at a dose of 1ml/kg/day, and in Group C there is also 30 patients were administered Sitopaladi churna at a dose 100 mg/kg/day. All the treated cases were assessed at each follow-up on the 14th day, 28th day, 42^nd day, and 56^th day, and post-follow-up was done after 1 month. The efficacy of drugs was assessed clinically and also based on investigations. Result: Signs and symptoms of Pranavaha srotodusti persisted maximum up to 28^th day follow up and on 42^ndday improvement in clinical signs and symptoms were found significant. Conclusion: In all cases, significant improvement was observed.