CLINICOPATHOGICAL SIGNIFICANCE OF SERUM PROLACTIN, CA19-9 AND C – REACTIVE PROTEIN IN COLORECTAL CANCER
AbstractThe incidence of colorectal cancer in India ranks fourth in men and third in women. Carcinogenesis is a process that involves a combination of mutations in oncogenes, tumour suppressor genes or epigenetic changes in DNA such as methylation. Our study aim to assess the clinicopathogical significance of serum Prolactin, CA19-9 and C – reactive protein in colorectal cancer. Population based case control study, which includes 120 participants and 120 healthy volunteers during the time period of one year. In our study we found, CA19-9 tumor markers reflected more specificity as compared to sensitivity and efficiency. Prolactin were significantly higher when compared with control. Further prolactin levels were significantly elevated in different stages of CRC malignancy as compared to controls. Our values demonstrated the progressive increase corresponding to clinical staging, tumor size and notable in relation to nodal status of colorectal squamous cell carcinomas. Our results may provide new approaches in the diagnosis, prognosis, and monitoring the risk factors and combines both gross as well as microscopic information to determine the probable diagnosis of colorectal cancer.
Article Information
44
986-989
519 KB
194
English
IJPSR
Padmini Shreyas Lambture * and Abdul Kayyum Shaikh
Department of Biochemistry, Ashwini Rural Medical College, Hospital & Research Centre Kumbhari, Solapur, Maharashtra, India.
phabbu18@gmail.com
22 August 2023
02 November 2023
30 December 2023
10.13040/IJPSR.0975-8232.15(3).986-89
01 March 2024
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