COENZYME Q10: A POTENTIAL BREAKTHROUGH IN PHYSIOLOGICAL DYSFUNCTIONS

Coenzyme Q₁₀ (ubiquinone) is a lipophilic benzoquinone substance. It is a pivotal component to the oxidative phosphorylation in the inner mitochondrial membrane of all aerobic cells as well as diminishes reactive oxygen species (ROS). Exogenous sources for CoQ₁₀ are grapes seed oil, walnuts, pistachios, spinach, and sesame seed. At present, it is being utilized as an antioxidant agent. Recent studies have revealed its neuroprotective action. In the present review, the comprehensive pharmacological benefits of coenzyme Q₁₀ on the central nervous system (CNS) has been revealed. Many studies were taken into considerations and compiled in accordance with their activities. Amongst those, the study using in-vitro models referring to neuronal toxicity and animal models of neurodegenerative diseases have been covered. Multiple outcomes have now evolved assisting the role of reactive oxygen species and neuroinflammation in the pathogenesis of the neurodegenerative disorder. The drug coenzyme Q₁₀ has been administered in a human subject with reference to their age and body weight. In case of increased oxidative stress and few selective cases of gene mutation, the energy production in mitochondria is highly impaired and the deficiency also happens in brain cells which is a leading cause in pathogenesis of premature aging and neurodegenerative diseases. Potential neuroprotective effects of coenzyme Q₁₀ have also been emphasized in several neurodegenerative disorders such as Parkinson’s disease (PD), Huntington’s disease and Alzheimer’s disease (AD). This article contributes a pervasive review on the utility of coenzyme Q₁₀ in the management as well as in the prevention of many illnesses as for example, hyperlipidemia, coronary artery disease, myocardial infarction and kidney disease.