Co(II), Ni(II), Cu(II) COMPLEXES OF SULPHUR CONTAINING SCHIFF BASE LIGAND-SYNTHESIS, SPECTROSCOPIC, MOLECULAR MODELLING AND ANTIMICROBIAL STUDIES
AbstractMetal (II) complexes of Co, Ni and Cu with Schiff base derived from 2, 4-Dihydroxy-5-acetylacetophenone and Aminothiophenol (DAAAP) were synthesized and characterized by elemental analysis, FTIR, IH NMR, electronic spectra, thermal analysis, magnetic susceptibility and conductometric measurements. On the basis of these studies, a six coordinated octahedral geometry has been proposed for all the complexes. The Schiff base and its complexes were tested for biological activity against various types of Gram-positive (Bacillus subtilis ATTC 6051 and S. pyogones ATTC 12600) and Gram – negative bacteria (Escherichia coli ATTC 11775 and Proteus vulgaris ATTC 13315) and Fusarium solani Martius and Aspergillus niger Fungus. It has been found that metal complexes are found to have sensitivity for inhibition of Gram‐positive more than Gram‐negative bacteria. All the metal complexes show antifungal activity and it is clear from the data that the complexes exhibit more antifungal activity compared to the parent ligand.
Article Information
47
5194-5202
861
756
English
IJPSR
P. S. Reddy
Department of Chemistry, University College of Science, Osmania University, Hyderabad, Telangana, India.
abbareddysaritha@hotmail.com
23 February 2019
06 June 2019
14 July 2019
10.13040/IJPSR.0975-8232.10(11).5194-02
01 November 2019
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