COMPARATIVE PHARMACEUTICAL QUALITY CONTROL TESTING OF DIFFERENT BRANDS OF PARACETAMOL TABLETS AVAILABLE IN THE TRINIDAD & TOBAGO, WEST INDIES
AbstractParacetamol tablets are popular over the counter (OTC) products among the patients as a good analgesics and antipyretics. The objective of this study was to compare the quality of the paracetamol tablet formulations those are locally available in Trinidad & Tobago pharmaceutical market manufactured by various pharmaceutical companies with pharmacopoeia standards. The four popular brands (A, B, C, D) of paracetamol conventional tablet of 500 mg strength were chosen. The paracetamol tablets were obtained from government hospital pharmacies as well as from local private pharmacies. To compare the quality of tablet formulations of different brands various official parameters like friability, weight variation, disintegration time, dissolution and drug assay tests were performed as per the pharmacopoeia. The result of all these parameters of different brands were in the pharmacopoeial limits so it could be concluded that marketed pharmaceutical tablets of paracetamol of these brands are safe, effective and efficacious as well as satisfy quality control limits of pharmacopoeia.
Article Information
11
2830-36
378
3163
English
IJPSR
Madan Mohan Gupta* and Madhulika Gupta
School of Pharmacy, Faculty of Medical Sciences, The University of the West Indies, St. Augustine, Trinidad & Tobago, West Indies
mmingupta@gmail.com
29 February, 2016
16 April, 2016
04 May, 2016
10.13040/IJPSR.0975-8232.7(7).2830-36
01 July, 2016
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