COMPARATIVE QUALITY EVALUATION OF SIX BRANDS OF ENTERIC COATED DICLOFENAC SODIUM TABLETS MARKETED IN ADDIS ABABAAbstract
Diclofenac sodium is a nonsteroidal anti-inflammatory drug (NSAIDs) with analgesic and antipyretic properties. Because of widespread use of this drug, quality control testing should be done for diclofenac marketed products to ensure safety; efficacy; accepted quality; rationality of use to protect public health. Quality of pharmaceuticals has been great concern of WHO. Drug cost needs to be reduced as health care costs continue to rise. Generic products need to be therapeutically equivalent to the brand innovator products. This can be achieved only when bioequivalent study is conducted to show whether a generic product is interchangeable with brand product or another generic product. In this study focus is given to evaluate and compare the quality of six different brands of enteric coated diclofenac sodium tablets marketed in Addis Ababa and also to study the different physicochemical properties of diclofenac sodium enteric coated tablets and to compare in vitro dissolution profile of six brands of diclofenac sodium delayed release tablets.
N.M. Joseph*, M. Degu and S. Palani
School of Pharmacy, College of Health Sciences, Addis Ababa University, Ethiopia.
18 June, 2017
22 November, 2017
26 November, 2017
01 December, 2017