COMPARATIVE SOLUBILITY STUDY OF CYCLODEXTRINS (Β- CD AND HPΒ- CD) AND ENHANCEMENT OF SOLUBILITY AND DISSOLUTION OF LORNOXICAM BY USING TERNARY COMPLEXATION
AbstractThe present investigation aimed to provide an approach for the solubility and bioavailability enhancement by Comparative solubility of cyclodextrins with Lornoxicam (LXM) by forming ternary Inclusion complexation (TIC). The phase-solubility and saturation solubility studies were executed in the existence of β-CD, HP-βCD and polymers. The drug/CD complexes were formulated and characterized further to confirm complex formation using DSC and FTIR. The solid dispersions (SDs) were formulated using double hydrophilization and accessed using FT-IR, DSC, and in-vitro testing. The equilibrium phase solubility and saturation solubility study for both binary and TIC showed a more significant solubility enhancement of LXM-HP β-CD- poloxamer-407(PXM 407) than LXM-β-CD. The FT-IR and DSC analysis confirmed the formation of a TIC amongst LXM-HP-βCD-PXM 407. The TIC demonstrated a higher Complexation Efficiency (CE) and stability constant than binary. The drug dissolution rate (DR) profile showed significant drug release from developed TIC and improved DR to a greater extent. From comprehensive study findings, it can be stated that employing the TIC of LXM-HP β-CD with PXM 407 might be a pragmatic choice to augment the LXM’s solubility and Drug release.
Article Information
42
3028-3036
948 KB
321
English
IJPSR
Nilima Navnath Khakal *, Nagesh Hanmant Aloorkar, Yogeshkumar Nanasaheb Gavhane and Atul Shivaji Gurav
Gaurishankar Education Society’s Satara College of Pharmacy, Degaon Satara, Maharashtra, India.
nilam.khakal@gmail.com
14 October 2022
24 November 2022
26 November 2022
10.13040/IJPSR.0975-8232.14(6).3028-36
01 June 2023