COMPARATIVE STUDY OF ANTI-ANXIETY AND ANTI-DEPRESSANT POTENTIALS OF LEAVES AND ROOT OF METHANOLIC EXTRACT FROM ACHYRANTHES BIDENTATA BLUME ON MICE

Anxiety and Depression is the most prominent and crippled Neuropsychiatric Disease. World Health Organization (WHO) reported is the most burdensome disease of society. We therefore aimed at evaluating the Anti-Anxiety and Anti-depressant potential using Achyranthes bidentata Blume (Chinese name Huainiuxi). This study compared Leaves and Root part of Achyranthes bidentata methanolic extract (ABME) on standardized mouse models of Anxiety and depression. The dried Leaves and Root was macerated with methanol separately and administrated and discern the dose of 100 mgk g^-1 p.o. and 200 mgkg^-1 p.o. of Achyranthes bidentata methanolic extract of Leaves (ABMEL) and the dose of 100 mgkg^-1 p.o and 200 mgkg^-1 p.o. of Achyranthes bidentata methanolic extract of Root (ABMER) were employed in Elevated Plus Maze test (EPM) and Open field test (OFT) with 1 mgkg^-1 i.p of Diazepam as a standard drug to assess the anxiolytic activity and Modified Forced Swim test (MFST) and Tail suspension test (TST) with 15 mgkg^-1 i.p. of Imipramine as a standard drug to assess the anti-depressant activity in Swiss albino mice. Substantial changes in all tested activities EPM, OFT in anxiety model and MFST, TST in depression model were observed for 28 days. The results revealed that ABMER (200 mgkg^-1p.o.) was more impetus due to the high amount of flavonoid content possess anti-anxiety and anti-depressant potential compared to ABMEL (200 mgkg^-1 p.o.) as well as ABMER (*p<0.05) produce significant effect compared to the standard group.