COMPARATIVE STUDY OF SPECIFIC ACOUSTIC IMPEDANCE AND TRANSPORT PROPERTIES OF SULFA COMPOUNDS USING ULTRASONIC VELOCITYHTML Full Text
COMPARATIVE STUDY OF SPECIFIC ACOUSTIC IMPEDANCE AND TRANSPORT PROPERTIES OF SULFA COMPOUNDS USING ULTRASONIC VELOCITY
R. Padmavathy * 1, E. Jasmine Vasantharani 1 and S. Santhakumari 2
Department of Physics 1, Seethalakshmi Ramaswamy College, Tiruchirappalli - 620002, Tamil Nadu, India.
Department of Physics 2, Srimathi Indira Gandhi College, Tiruchirappalli - 620002, Tamil Nadu, India.
ABSTRACT: Measurement of ultrasonic velocity in non-aqueous solution gives information about the behavior of solution such as molecular association and disassociation. The attraction and repulsion between the molecules of the components involved show considerable effect upon the physical and chemical properties of a solution such as density, viscosity, and ultrasonic velocity. The ultrasonic velocity data combined with density and viscosity provides the standard means for determining the acoustical parameters and internal pressure, free volume. The Specific acoustic impendence in solutions can be used as a tool to estimate the strength of intermolecular attraction. Internal pressure (πi) and free volume (Vf) are the transport properties, which are useful in understanding the intra and intermolecular interactions. Internal pressure gives an idea of the solubility characteristics. Sulphanilamide is a parent compound and also the potent antibiotic which is important in urinary tract infections and meningococcal meningitis profilaxes 1. Another sample Sulphadiazine is the Sulphonamide potent antibiotic, and it is a competitive inhibitor of the bacterial enzyme dihydropteroate synthesis.
Specific Acoustic impedance, Transport properties, Ion-ion interaction, Ion-solvent interactions
INTRODUCTION: The passage of ultrasonic waves through solutions and liquids disturb the equilibrium between solute and solvent molecules. The velocity of such a wave is the thermodynamic quantity and is related to physio-chemical properties of the medium 2. Ultrasonic velocities have been adequately employed in understanding the nature of molecular interaction in pure solutions 3. The behavior of Specific Acoustic impedance of the solution emphasizes the strong solute-solvent interactions occurring in the Solution.
Internal pressure, the free volume is reliable and easily measurable parameters, which are fundamentally responsible for the structure of liquids/solutions. Internal pressure depends on the nature of the solvent, and solute interactions may lead to contraction or expansion at a constant temperature 4.
EXPERIMENTAL ANALYSIS: The density of the solution is measured with 25ml of specific gravity bottle with an accuracy of 0.0001gm/cc. Cannon Fenske viscometer is used for the viscosity measurements, with an accuracy of ± 0.5%. Mittal’s interferometer of frequency 2MHZ, with an accuracy of ±0.5m/s, is used for the measurement of ultrasonic velocity.
Specific Acoustic impedance (z), internal pressure (πi) and free volume (vf) of both the salts are evaluated by using the formulae
Specific acoustic impedance (Z) = ρu (Rayl)
Internal pressure (πi) = bRT [kη/u] 1/2ρ2/3/M7/6 atms
Free volume (vf) = [Meff u/kη] 3/2cc
RESULTS AND DISCUSSION: In the present Work, the specific acoustic impedance of Sulphadiazine, a dip is observed at 0.01 molality at all temperatures. These may be due to the weak solute-solvent interaction taking place in the solution, and in (another sample) sulphanilamide, the linear increase in *Z with the molality at a given temperature is observed in the solution. This linear increasing due to the effect of strong solute-solvent interaction existing in the solutions 5. This may be due to the effect of solute-solvent interaction occurring in the solution 6 as shown in Fig. 1 & 2 and Table 1 & 2.
TABLE 1: SPECIFIC ACOUSTIC IMPEDANCE (RAYL) SULPHANILAMIDE
TABLE 2: SPECIFIC ACOUSTIC IMPEDANCE (RAYL) SULPHADIAZINE
The internal pressure is a single factor, which varies due to all internal interactions. There is a non-linear variation with respect molalities and temperatures are observed in Sulphadiazine and Sulphanilamide. At 0.01 molality there is an abrupt change noticed in both systems as shown in Fig. 3 & 4 and Table 3 & 4.
TABLE 3: INTERNAL PRESSURE (ATMS) SULPHANILAMIDE
TABLE 4: INTERNAL PRESSURE (ATMS) SULPHADIAZINE
Hence, there is a weak solute-solvent interaction taking place in the solutions. The reduction in internal pressure may be due to the breaking up of the structure of the solvent medium due to the addition of solute in the solvent 7. The Internal pressure decreases with rising in temperature because when the temperature is increased, there is a tendency for the ions to move away from each other, reducing the possibility for interaction, which may further reduce the cohesive forces and ultimately leads to a decrease in the internal pressure 8, 9. Free Volume is the free space available for the molecule to move 10. The structure making and breaking effects of these samples are confirmed by decreasing and increasing values of free volume concerning molalities and temperatures 11, 12 as shown in Fig. 5 & 6 and Table 5 & 6.
TABLE 5: FREE VOLUME (cc) SULPHANILAMIDE
TABLE 6: FREE VOLUME (CC) SULPHADIAZINE
From the analysis of Sulphadiazine and Sulphanilamide, it is observed that the systems seem to be conditioned by repulsive forces; hence, the solute-solvent interaction is weak.
CONCLUSION: Sulfonamide compounds identified as chemotherapeutic agents, possess a broad spectrum of biological properties 13. Sulfanilamide is a potent antibiotic because this drug undergoes metabolic alterations in tissues 14.
Sulphadiazine is essential for folic acid synthesis used in the treatment of rheumatic fever and meningococcal meningitis.
The Weak solute-solvent interactions observed in the non-aqueous sulfa drug solution is based on the thermodynamical and acoustic impedance analysis which reveal the entry of these salts into the formamide introduce a structure breaking tendency in these samples.
CONFLICT OF INTEREST: Nil
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How to cite this article:
Padmavathy R, Vasantharani EJ and Santhakumari S: Comparative study of specific acoustic impedance and transport properties of sulfa compounds using ultrasonic velocity. Int J Pharm Sci & Res 2014; 5(9): 3775-78. doi: 10.13040/IJPSR.0975-8232.5(9).3775-78.
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R. Padmavathy *, E. J. Vasantharani and S. Santhakumari
Department of Physics, Seethalakshmi Ramaswamy College, Thiruchirappalli, Tamil Nadu, India.
07 March 2014
16 May 2014
26 June 2014
01 September 2014