COMPARISON OF ALCOHOLIC AND AQUEOUS EXTRACT OF ROOT OF AERVA JAVANICA FOR ITS NEPHRO-PROTECTIVE EFFECT IN CISPLATIN-INDUCED RENAL TOXICITY

Aerva javanica belonging to family (Amaranthaceae) roots and flowers are reported to possess medicinal properties against rheumatism and kidney problems. The present work is to evaluate the nephroprotective effect of Aerva javanica by cisplatin induced renal toxicity in adult male albino rats of Wistar strain. The effect ofalcoholic extract and aqueous extract were evaluated at 200 mg/kg and 400 mg/kg, in rats against nephrotoxicity induced by administration of cisplatin through intra peritoneal route. Various serum parameters were studied along with histopathological examination of kidneys in each treatment group. Both the extracts were compared to the ursolic acid at the dose of 150 mg/kg as a standard drug. Alcoholic extract was foundto have significant nephroprotective activity. The levels of urea, creatinine, albumin and total protein in the serum were normalized after treatment with alcoholic extract at both the doses. The alcoholic extract at the dose of 400 mg/kg shows similar result as compared to the reference standard ursolic acid. The alcoholic extract of A. javanica possesses marked nephroprotective activity and thus can have a promising role in the treatment of acute renal injury.