COMPARITIVE IN VITRO EVALUATION OF DIFFERENT COMMERCIALLY AVAILABLE BRANDS OF PANTOPRAZOLE TABLETS
AbstractThe present study is concerned to investigate and compare physico-chemical properties( thickness, hardness, weight variation, friability and disintegration), invitro dissolution of the drug along with drug content(assay) for different brands of tablets containing pantoprazole (40mg, 20mg) prepared by various pharmaceutical industries under different trade names. All the brands passed all the official tests as prescribed by the Pharmacopoeia. All the brands were within the limit when tested for Thickness, Weight variation, Hardness, Friability and Disintegration. The amount of drug obtained and percentage purity is less when compared to that of labeled claim. Among the four brands, both 40 mg(B) and 20 mg(b), brand 1 i.e. B1 and b1 was found to have more amount of the drug and brand 2 i.e. B2 and b2 was found to have less amount of the drug. The U.V. Spectrophotometric method for the assay of Pantoprazole tablets used in this study is simple, inexpensive, reproducible and easy to use and could be used in routine monitoring of the quality of the pantoprazole sodium tablets, especially in the absence of high technology equipment.
Article Information
28
1108-1111
643KB
2498
English
IJPSR
T. Neelima Rani*, Ch. T. Lalitha Kumari , B. Mallikarjun Reddy , D.R. Brahma Reddy
Assistant Professor, Nalanda Institute of Pharmaceutical Sciences, Kantepudi, Sattenapalli, Andhra Pradesh, India
19 December, 2011
25 January, 2012
27 March, 2012
http://dx.doi.org/10.13040/IJPSR.0975-8232.3(4).1108-11
01 April, 2012
Download