COMPLEX DRUG DELIVERY SYSTEMS

The majority of current drug delivery systems are existed as water-insoluble drug delivery systems but rarely water-soluble drug delivery systems. Low aqueous solubility is a common problem in pharmaceutical development. About 40% of commercialized drugs and as many as 90% of drugs in the discovery are low aqueous soluble. When given through traditional dosage forms, such drugs fail to be soluble and have limited bioavailability, so they tend to show limited therapeutic effect and often fail. Various methods to solubilize drugs usually involve a combination of pH modifiers, salt forms, co-solvent systems, surfactants, or complexation. A complex drug system is generally a complex system incorporated with API and compatible excipients to produce the desired effect. Complex drug systems are simply referred to as uncommon products that were not typical tablets. However, with the rise of insoluble API biologics, complex drug systems are quickly gaining importance. Most used complexes include phosphor lipid complex, chitosan complex, cyclodextrins complex, phosphatidylcholine complex. Complex drug systems are employed in various areas for treating various clinical conditions like insulin complexes for antidiabetic treatment, platinum complexes for anticancer treatment, cyclodextrins complexes for schizophrenia. They are developed by solubilization & bioavailability enhancement techniques, drug-eluting systems, sterile products, highly potent API or controlled substances.