COMPUTATIONAL UNDERSTANDING OF SELECTIVE MMP INHIBITORS IN COPDAbstract
Chronic Obstructive Pulmonary Diseases (COPD) refers to multiple lung diseases, is the occurrence of chronic bronchitis and emphysema, a pair of commonly co-existing diseases of the lungs in which the airways become narrowed because of inflammatory cells like neutrophils, CD8 cells and macrophages. These cells produce the Matrix metalloproteinases (MMPs), cathapsins and other proteinase enzymes. In humans there are 26 MMPs are present, which are classified in to six categories based on the structure of their substrate, sequence similarity and characteristics of structural domain. Structurally, MMPs are similar, but functionally different – but the general function of MMP is to degrade the extracellular matrix according their specific substrates. From the literature, three MMPs [MMP-09, MMP-12 & MMP-14] which are implicated in COPD were selected. Our aim is was to achieve a meaningful understanding of selectivity of individual ligands towards their enzymes, while our interest also is to find explanations for selective and non-selective inhibitors.
P. Devika*, R. Voleti Sreedhara , T. C. Venkateswarlu and N.D. Prasanna
C/o - P. Koteswra Rao, Venue residency, House no: 20-14, Flat no- 5, Narasimharao street, Near lakshmi takis, Machilipatnam, Krishna dist- 521001, Andhra Pradesh, India
17 September, 2012
11 October, 2012
29 November, 2012
01 December, 2012