COUMARIN RING: A BIOLOGICALLY ACTIVE SCAFOLD
AbstractCoumarin, natural or synthetic, has become an interesting subject of investigation for many researchers due to its wide range of biological activities. Coumarin scaffold has an important role in anticancer drug development because many of its derivatives have shown anticancer activity on various cell lines. The action of coumarins on tumour cells is carried out via different mechanisms and some of them show very good selectivity toward the cancer cells. A brief literature review (2010-2015) on coumarins as potential anticancer drugs is given in this work, which can serve as an excellent tool for future investigations on the design and synthesis of such derivatives. Coumarin is available naturally and synthetically from various methods; due to its wide range of biological activities has become an interesting subject of research from many researchers. Coumarin forms a scaffold with different heterocyclic rings and shows different biological activities like anticancer, anti-tubulin, anti-inflammatory, anti-virus, etc. The coumarin nucleus is now used to develop novel compounds for various life-threatening diseases.
Article Information
16
1988-2000
1411 KB
415
English
IJPSR
Pavankumar D. Chopade *, Anwar Rafique Shaikh and Agnes Sara Sabu
M. C. E. Society’s Allana College of Pharmacy, Azam Campus, Camp, Pune, Maharashtra, India.
chopadepavan@gmail.com
31 July 2021
23 December 2021
27 March 2022
10.13040/IJPSR.0975-8232.13(5).1988-00
01 May 2022
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