CURCUMIN DERIVATIVE: AN EMERGING ANTI-INFLAMMATORY AGENTAbstract
Numerous disorders are caused by inflammation, and recent epidemics have prompted public health concerns. The fact that there are so many anti-inflammatory medications available doesn’t change the fact that they frequently don’t work because they pose a severe risk of gastrointestinal toxicity with both acute and chronic use, hematologic toxicity with acute use, and nephrotoxicity with chronic use. Curcumin’s clinical value was, however, constrained by its low absorption. Therefore, it is crucial to find new anti-inflammatory medications, and natural products are a great place to start. One such natural substance, curcumin, is a promising therapeutic candidate because of its stability, solubility, and low toxicity. Research has indicated its inhibitory effect on prostaglandin E2 and COX-2 protein formation, as well as on phorbol ester- and CD-induced COX-2 mRNA expression and PGE2 synthesis, among other things. The mechanisms either entail inhibiting cyclooxygenases (COX) and other inflammatory enzymes. This study covers the current state of knowledge with an emphasis on the anti-inflammatory properties of curcumin and their potential molecular pathways.
Shalini Awasthi * and Cheenu Bhargava
Department of Pharmacology, Advance Institute of Biotech and Paramedical Sciences, Kanpur, Uttar Pradesh, India.
19 July 2022
29 August 2022
20 October 2022
01 April 2023