DEPRESSION: UNDERSTANDING THE PATHOPHYSIOLOGY AND TREATMENT MODALITIES
AbstractDepression is accepted as a condition of misery and is treated as a disorder that includes mental and emotional disorders. Depression is a deadly disease that affects about 5% of the general population. In addition, depression is a heavy burden on patients and families. Furthermore, many epidemiological studies have shown that the occurrence of depressive disorders in the general population is increasing at an alarming rate. Depression is the most common form of emotional disorder, from a very mild condition to severe depression associated with hallucinations and delusions. In addition, altered levels of serotonin and other biogenic amines have also been shown to contribute to neuromodulatory disturbance in the etiology of depression. According to monoamine theory in depressive disorder, patients with major depression have shown biochemical symptoms which may change monoamine neurotransmitters, specifically nor-epinephrine and serotonin. Clinical data suggested that dopamine is also involved in the pathophysiology and treatment of depression.
Article Information
7
1611-1621
535 KB
427
English
IJPSR
Anuradha Pannu and Abhilasha Ahlawat *
Department of Pharmaceutical Sciences, Maharshi Dayanand University, Rohtak, Haryana, India.
abhilasha.rp.pharma@gmail.com
13 July 2022
11 September 2022
20 October 2022
10.13040/IJPSR.0975-8232.14(4).1611-21
01 April 2023
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