DESIGN AND CHARACTERIZATION OF PULSATILE DRUG DELIVERY SYSTEM OF LERCANIDIPINE
AbstractThe purpose of the present investigation is to formulate and evaluate Lercanidipine pulsatile drug delivery system by press coating method. The inner core tablets were prepared by using direct compression method by using cross-carmellose sodium (Ac-Di-Sol), sodium starch glycolate, crospovidone as super disintegrants. The drug polymer interaction was investigated by FTIR and their results directed further course of formulation. The inner core tablets were evaluated for various post compression parameters like Tablet hardness, Friability, Weight variation, Drug content and in vitro dissolution for both core and coated Tablets. The disintegration time for the core tablet was found to be 35sec and the percentage drug release for the optimized formulation (F7) was 96.1% in 30mins. The Press coat tablets containing HPMC and Ethyl cellulose as a barrier layer. The press coat tablets were evaluated for post compression parameters and were found to be in limits. The percentage drug release of optimized formulation Ethyl cellulose (F7P3) was found to 99.65% at the end of 8hrs
Article Information
39
1275-1281
542KB
1064
English
IJPSR
Basu Venkateswara Reddy * and Kaluva Navaneetha
Professor and Principal, Sankar Reddy Institute of Institute of Pharmaceutical Sciences, Salakalaveedu (v), Bestavaripeta (M), Prakasam, Andhra Pradesh, India
basu.pharmacist@gmail.com
26 August, 2016
12 October, 2016
06 December, 2016
10.13040/IJPSR.0975-8232.8(3).1275-81
01 March, 2017
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