DESIGN AND DEVELOPMENT OF FAST DISSOLVING TABLETS OF HYDROCHLOROTHIAZIDE AND ATENOLOL CO-CRYSTALS
AbstractHydrochlorothiazide (HCT) is a class IV drug which has limited solubility and permeability, for overcome this problems co-crystallization method is used. Co-crystallization is the process to enhance the physical properties of drug molecule especially the solubility. HCT belongs to diuretic category and Atenolol (ATL) belongs to Beta blocker category they are combined for use in tablet formulation. Co-crystallization was used to combine two drugs in single solid phase and thus to achieve new approach for combination therapy to treat hypertension. Using the new approach co-crystals of ATL with HCT was prepared. Co-crystallization of two drugs were carried out by using solvent evaporation and solution co-crystallization method. The saturation solubility was done to evaluate the solubility of co-crystals. Comparative drug release study was carried out between co-crystals and marketed formulation. The prepared co-crystals have shown several times faster release than marketed tablet and co-crystals were characterized by using DSC, FTIR and SEM
Article Information
32
4368-74
563
1666
English
Ijpsr
O. S. Bhandwalkar *, M. U. Bhandwalkar, D. M. Ghadge, P. S. Dhekale, U. K. Jamdade
Gourishankar Institute of Pharmaceutical Education and Research, Limb, Satara, Maharashtra, India
omkargurav4442@gmail.com
07 April, 2015
22 June, 2015
29 July, 2015
10.13040/IJPSR.0975-8232.6(10).4368-74
01 October, 2015
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