DESIGN AND DEVELOPMENT OF IONTOPHORETIC DRUG DELIVERY SYSTEM OF L-TYROSINE
AbstractThis study was aimed to design and develop iontophoretic drug delivery of L-Tyrosine in the treatment of phenylketonuria. The In-house iontophoretic drug delivery device was designed and validation was performed respect to Current intensity, Voltage, and Power Resistance. The study was also focused various parameters such as effect of different drug concentrations (2.5mg/5ml, 5mg/5ml, 10mg/5ml, 15mg/5ml) and effect of different current intensities (0.1mA/cm2, 0.25mA/cm2, 0.5mA/cm2, 0.75mA/cm2). The results concluded there is a significant increase in Percentage of drug release in iontophoretic drug delivery of L-Tyrosine from 1-47 folds when compare to passive diffusion. The drug release increased up to certain concentration range after that if concentration increased means there is a decrease of drug release due to skin boundary saturation. Among the four drug concentrations 2.5mg/5ml,5mg/5ml showed good reliable release. 10mg/5ml, 15mg/5ml showed very less release due to saturation. Among the different current intensities the drug release increased with increase of current intensities.
Article Information
40
5382-5388
456KB
1154
English
IJPSR
N. Kirubakaran*, K. Reeta vijaya Rani, A. Anithaa and R. Senthamarai
Department of Pharmaceutics, Periyar college of Pharmaceutical Sciences, Trichy, Tamil Nadu, India.
kirubakaran_14@yahoo.co.in
12 May, 2014
26 July, 2014
19 November, 2014
http://dx.doi.org/10.13040/IJPSR.0975-8232.5(12).5382-88
01 December 2014
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