DESIGN AND EVALUATION OF AMOXICILIN TRIHYDRATE FLOATING GRANULES PREPARED BY MELT GRANULATION TECHNIQUE
AbstractThe purpose of this study was to design and evaluate Amoxicillin trihydrate floating granules by melt granulation technique using Gelucire 43/01 and Campritol 888 ATO as lipid carriers. Polymers HPMC K4M and Ethyl Cellulose as release rate modifiers. The granules were evaluated by FTIR studies, differential scanning calorimetry, Scanning Electron microscopy, drug content, in vitro floating ability and in vitro drug release. The optimized formulation showed good floating ability and 98% drug was released in 12 h with both lipid carriers. The drug release from optimized formulations F3 and F9 followed zero order patterns and governed by Non-Fickian mechanism which was confirmed by the ‘n’ values of Koresmeyer Peppas equations. Formulations of Gelucire 43/01 had shown superior retardation and floating characteristics compared to that of Campritol 888 ATO. In conclusion, hydrophobic lipid, Gelucire 43/01 can be considered as an effective carrier for design of a multiunit floating drug delivery system of highly water – soluble drugs such as Amoxicillin trihydrate.
Article Information
15
1478-1485
626
1382
English
IJPSR
U. K. Gondrala, Shayeda* and V. Bejjenki
Department of Pharmacy, University College of Pharmaceutical Sciences, Kakatiya University, Warangal, Telangana, India.
rishit.usha@gmail.com
01 July, 2017
07 September, 2017
10 September, 2017
10.13040/IJPSR.0975-8232.9(4).1478-85
01 April, 2018
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