DESIGN AND EVALUATION OF DICLOFENAC SODIUM BUCCAL MUCOADHESIVE FILM BY SOLVENT CASTING TECHNIQUE
AbstractMucoadhesive buccal patches containing diclofenac sodium were prepared using the solvent casting method. HPMC used as bioadhesive polymer and different ratio of propylene glycol and glycerin also used. FT-IR and UV spectroscopic methods revealed that there is no interaction between Diclofenac sodium and polymers. The patches were evaluated for their physical characteristics like mass variation, drug content uniformity, folding endurance, surface pH, and in vitro drug release, in vitro buccal permeation study. Incorporation of DMSO generally enhanced the release rate. Swelling index was proportional to the concentration of HPMC. Optimized patches (F) showed satisfactory bioadhesive strength. The surface pH of all batches was within ± 0.4 units and thus no mucosal irritation is expected. Patches containing of F5 had higher bioadhesive strength with sustained drug release as compared to patches with other ratios of polymer. Data of in-vitro release from patches were fit in to different equations and kinetic models to explain release kinetics. The models used were zero and first-order, Hixon-Crowell, Higuchi and Korsemeyer-Peppas models equation. The optimized patch demonstrated well in-vitro results.
Article Information
19
1767-1775
579KB
1656
English
IJPSR
G. Lakshmana Murthy *, V. Raghu Vamsi , Tirumala Devi , N. Narendra Babu, Sravya Ch , K. Masthaniah , Shaik Harun Rasheed and P. Kranti Kumar
Department of Pharmaceutics, Jagans College of Pharmacy, Nellore, Andhra Pradesh, India
murthympharm@gmail.com
22 November, 2013
10 February, 2014
28 March, 2014
http://dx.doi.org/10.13040/IJPSR.0975-8232.5(5).1767-75
01 May, 2014
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