DESIGN AND EVALUATION OF LAMOTRIGINE ORAL SUSTAINED RELEASE TABLETSAbstract
Objective: The objective of the study is to design and evaluate oral sustained release tablet of lamotrigine using polymer such as HPMC K 4M, HPMC K 100M and methocel E50 LV at 15%, 25%, and 35% Concentration range.
Methods: All the selected ingredients were weighed and passed through 40# sieve, blended in a Poly Bag except Magnesium Stearate for 10 minutes. The resultant mixture was made in to a wet mass and passed through 20# sieve in order to obtain granules. These granules were air dried and passed through 30# sieve. These dried granules were lubricated with Magnesium stearate, which was previously passed through 60# Sieve and then punched using single punching machine.
Results: Pre-compression character such as compressibility index, angle of repose and Post-compressional characteristics such as weight variation, hardness, diameter, thickness, friability were found to be with in the I.P limits. In vitro release profile was studied using HPMC K4M, HPMC K 100M and methocel E50 LV at three different concentration. The percentage cumulative amount of drug release was found to be 82.72% in 12 hrs, 70.69% in 12hrs and 97.80% in 4hrs respectively for the entire batch at 15% polymer concentration.
Conclusion: The study proves that fluctuation in the drug release is overwhelmed when lamotrigine is administered in the form of SR tablet.
S. Sangeetha*, G. Harish, T. Raghuprasath and N. Damodharan
Department of Pharmaceutics, SRM College of Pharmacy, SRM University, Kattankulathur, Kanchipuram District, Chennai, Tamil Nadu, India
12 September, 2010
16 November, 2010
14 January, 2011
01 February, 2011