DESIGN AND EVALUATION OF ONCE DAILY LOSARTAN POTASSIUM SUSTAINED RELEASE MATRIX TABLET
AbstractThe aim of the study was to develop sustained release matrix tablet of Losartan potassium and to evaluate its efficacy in reducing hypertension. In this experiment, sustained release matrix tablets were prepared by direct compression method and Methocel K4M CR and Methocel K100M CR were used as polymer. The evaluation involves three stages: the micromeritic properties evaluation of powder blend, physical property studies of tablets and in-vitro release kinetics studies. The powder blend was evaluated for angle of repose, loose bulk density, tapped bulk density, Carr’s index, Hausner’s ratio, moisture content and total porosity and the tablets were evaluated for hardness, friability, thickness, drug content and in vitro dissolution parameters. The weight variation was observed to be within the prescribed limits for each formulation. In vitro release studies were carried out using USP apparatus type II at 100 rpm and dissolution medium consisted of 0.1N hydrochloric acid for the first 2 hours and phosphate buffer pH 6.8 from 3 to 24 hours, maintained at 37±0.5°C. Drug release at different intervals was measured by UV-visible spectrophotometer at 205 nm. In this study the F9, F10 and F12 formulations showed better drug release compared to others. The release of drug was plotted in zero order, 1st order, Higuchi, Korsemeyer-Peppas and Hixson-Crowell release pattern. Kinetic modeling of in vitro dissolution profiles revealed that the drug release mechanism from all proposed formulations followed anomalous type or non-Fickian transport. The release of drug was extended for 24 hour by polymer combination which indicated the usefulness of the formulations for sustained release drug delivery.
Article Information
29
519-525
689KB
1456
English
IJPSR
Mohi Uddin*, Shimul Halder , Uttom Kumar and Abu Shara Shamsur Rouf
Department of Pharmacy, University of Chittagong , Chittagong-4331, Bangladesh
mohiuddin@cu.ac.bd
24 September, 2013
20 November, 2013
12 January, 2014
http://dx.doi.org/10.13040/IJPSR.0975-8232.5(2).519-25
01 February, 2014