DESIGN AND IN-VITRO CHARACTERIZATION OF CHLORDIAZEPOXIDE EFFERVESCENT FLOATING TABLETS

Chlordiazepoxide is a sedative and hypnotic medication which is used to treat anxiety, insomnia, and withdrawal symptoms from alcohol and/or drug abuse. Chlordiazepoxide has a medium to the long half-life, but its metabolite is pharmacologically active and has a very long half-life. In the present work, an attempt has been made to develop effervescent floating tablets of Chlordiazepoxide. Methocel K4M, Methocel K15M & Xanthan gum were employed as polymers. All the formulations were prepared by direct compression method using 6mm flat punches. The blend of all the formulations showed a better angle of repose, bulk density, tapped density, compressibility index, and Hausner’s ratio. The prepared tablets exhibited excellent hardness, friability, drug content, buoyancy lag time, duration of buoyancy, swelling index. Among all the formulations, the F7 formulation floated for more than 12 h, showed short buoyancy lag time of 96±0.92 seconds, high swelling indices of 2.4±0.12 %, and showed maximum cumulative percent drug release of 98.21±0.24 % in 12 h. Consequently, formulation F7, made using xanthan gum in 10mg/unit tablet weight concentration, was considered as an optimized formulation. The mechanism of drug release was found to be following zero-order release kinetics and non-Fickian diffusion.