DESIGN AND IN-VITRO EVALUATION OF INDAPAMIDE SUSTAINED RELEASE TABLET USING METHOCEL K15 MCR AND METHOCEL K100M LVCRAbstract
Indapamide, a low-dose thiazide-type diuretic, is used for the treatment of essential hypertension. In this study, we developed an indapamide sustained release formulation using Methocel K15M CR and Methocel K100M LVCR, starch 1500, talc and magnesium stearate considering technical feasibility and performed a comparative study with the release pattern. The tablets showed sustained release curves at pH 6.8 phosphate buffer for up to 12 h. The granules showed satisfactory flow properties, compressibility index and drug content etc. All the tablets complied with pharmacopoeial specifications. The results of dissolution studies indicated that the formulations F-6 and F-8 could extend the drug release up to 12 h. The data obtained from the dissolution profiles were compared in the light of different kinetics models and the regression coefficients were also compared. Kinetic modeling of in vitro dissolution profiles revealed the drug release mechanism ranges from diffusion controlled or Fickian transport to anomalous type or non-Fickian transport, which was only dependent on the type and amount of polymer used. The drug release followed both diffusion and erosion mechanism in all cases. This study explored the optimum concentration and effect of polymer(s) on Indapamide release pattern from the tablet matrix for 12 h period.
S. Sanam, S. Halder*, M. L. Shuma , A.K.L. Kabir , H.O. Rashid and A.S.S. Rouf
Lecturer, Department of Pharmaceutical Technology, University of Dhaka, Dhaka-1000, Bangladesh
07 December, 2011
15 February, 2012
27 March, 2012