DESIGN, DEVELOPMENT, AND CHARACTERIZATION OF BUCCAL MUCOADHESIVE PATCH LOADED WITH CLINDAMYCIN HYDROCHLORIDE AND CURCUMIN USING DESIGN EXPERT SOFTWARE FOR THE TREATMENT OF PERIODONTITIS

Periodontitis is a widespread oral gum infection having multiple antibiotics for the treatment, but large oral doses and the emergence of antibiotic resistance constrain their usage. The goal of this study was to develop and characterize buccal mucoadhesive patches made of clindamycin and polymers for the treatment of Periodontitis. Patches were developed by solvent casting method using Clindamycin Hydrochloride, an herbal constituent of Curcumin, and polymers like Polyvinyl Alcohol, and Hydroxy Ethyl Cellulose. Eight trial patches were developed by keeping the drug ratio constant and varying the concentration of different polymers. The optimized patch concentration was chosen to formulate the buccal mucoadhesive patch to treat periodontitis. Optimization was conducted by Design Expert Software (DoE) using 2³ full factorial designs by taking three independent variables as factors and two dependent variables in-vitro Drug release (Y1) and Drug content (Y2). Prepared buccal mucoadhesive patches were flexible and showed the highest efficacy in the inhibition of oral microorganism species like Porphyromonas, Streptococcus, Actinomyces, and Candida albicans. The optimized patch was analyzed for interaction study using FTIR and DSC analysis, the tensile strength was analyzed using a Tensiometer and other parameters like weight uniformity, film thickness, content uniformity, surface pH, folding endurance, and tensile strength. The in-vitro release study showed an initial burst release of the drug followed by a sustained release for up to 24 hours. The developed Buccal Mucoadhesive Patch gives sustained action for up to 24 hours compared to other dosage forms.