DESIGN, DEVELOPMENT AND EVALUATION OF GASTRIC FLOATING IN-SITU GEL OF PIROXICAM

The present study involves the formulation and evaluation of floating in-situ gel containing piroxicam for the treatment of arthritis. In the FTIR and DSC study for compatibility of piroxicam with polymers, there are no significant changes observed so it is confirmed the absence of drug-polymer interactions. The gastric floating in-situ gel was prepared by using Sodium Alginate, HPMC K 200 M & other ingredients. The prepared situ gel of piroxicam was evaluated for pH, gelling capacity, floating lag time, total floating time, drug content, viscosity, in-vitro drug release. An optimization study was carried out by using was 3² factorial designs to find the effect of independent variables, i.e., amount of Sodium Alginate (X1) and HPMC K 200 M (X2) on dependent variables i.e., floating lag time & % CDR. The results showed that all the formulations exhibited a very short floating lag time. Most of the formulations floated within 1 min. All the formulations exhibited a basic pH in the range of 6.7 to 7.9 which is suitable for oral consumption and gastric delivery. Increasing the calcium carbonate content in the formulation simultaneously increased the viscosity at all polymer concentrations. The comparing G1 to G9 formulations it was observed that the drug release pattern of formulation G1 is about 99.25% at the end of 12 h & have sufficient gelling property, viscosity & floating lag time so it is selected as an optimum batch. 3² full factorial design optimization technique was successfully used in the development of this in-situ gel.