DESIGN, FABRICATION AND EVALUATION OF BIOADHESIVE BUCCAL TABLETS OF CILNIDIPINE
AbstractBuccal drug delivery is the most suited route for local as well as systemic delivery of drugs. The purpose of this study was to develop and optimize formulations of mucoadhesive tablets of Cilnidipine with an objective to enhance therapeutic efficacy, bioavailability and was developed to administer into the unconscious and less-co-operative patients. Cilnidipine buccal tablets were prepared by direct compression method using various concentrations of mucoadhesive-polymers such as Carbopol and Hydroxyl propyl methylcellulose (HPMC) the Prepared Tablets were evaluated for their weight variation, Hardness, thickness, Friability, swelling-index, drug content uniformity and in-vitro release studies. The infra-red (IR) spectra showed no interaction, and Physico-chemical characteristics were found within the limit. Swelling index increases with increasing concentration of polymers. The formulation F8 showed a promising Bio adhesive strength and in-vitro drug release of 98.29% for 8 hrs thus can be selected as an optimized formulation of mucoadhesive buccal film.
Article Information
30
1533-1538
814 KB
217
English
IJPSR
Y. Indira Muzib * and D. Nagamani
Institute of Pharmaceutical Technology, Sri Padmavati Mahila Viswavidyalayam, (SPMVV) Tirupati, Andhra Pradesh, India.
yindira1415@gmail.com
15 March 2024
16 April 2024
29 April 2024
10.13040/IJPSR.0975-8232.15(5).1533-38
01 May 2024
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