DESIGN, FABRICATION, AND EVALUATION OF BUCCAL DRUG DELIVERY OF BENIDIPINE HYDROCHLORIDE

The present study involves the formulation development and in-vitro evaluation of benidipine hydrochloride buccal tablets. Designed to prolong the time of release of drug and also to enhance the better bio-availability of the drug. Benidipine hydrochloride is a long-acting calcium channel blocker. It exerts its antiangial, antihypertensive action through blocking the influx of ca ions through voltage gated L-type ca channels to the pheripheral vascular smooth muscle cells, coronary smooth muscle cells and to the myocardial cells. And having biological half life 1-2 hrs, extensive protein binding need to formulate an dosage form. Benidipine hydrochloride buccal tablets were prepared by using direct compression method. Total eight formulations were prepared by using different polymers viz., Sodium alginate, Chitosan, Carbopol 934, HPMC, in various ratios. The nature of the polymer influences the physical and release characteristics of the buccal tablets. Preformulation studies were carried out before formulation design. Preformulation results showed good flow properties and all results are within specified limits. Compatibiity for drug and excipient was carried by FT-IR and result was showed no interaction. In-vitro dissolution studies was carried out by using 6.8 phosphate buffer. All the formulations showed good dissolution profiles. In Among all the formulation (F1-F8), F7 Containing carbopol 934 with HPMC, showed better mucoadhesive strength (28.80) and release of drug (99.92%) from buccal tablet for 6 hour was observed.