DESIGN, FORMULATION AND IN VITRO EVALUATION OF MICROSPONGES BASED GEL FOR TOPICAL DELIVERY OF KETOCONAZOLE

The aim of the present study was to formulate topical microsponge-based delivery system containing ketoconazole for controlled release of the drug for proficient treatment of fungal infections. Ketoconazole loaded microsponges were prepared by quasi emulsion solvent diffusion method using ethyl cellulose N22 polymer with varied drug polymer ratios. The prepared microsponges were characterized by SEM, FTIR, and evaluated for surface morphology, % drug loading, particle size, % entrapment efficiency and in vitro drug release. The effect of formulation variables such as drug to polymer ratio, stirring speed on the physical characteristics of microsponges was examined. Compatibility studies using UV and FTIR indicated that there is no chemical interaction between drug and polymers. SEM studies revealed that the prepared micro sponges were spherical and porous with a mean particle size of 82.25μm. The formulations were subjected to in vitro release studies for 8 hr which showed sustained release. Microsponges were further incorporated in to carbopol gel formulation for topical delivery. Prepared gel formulations were evaluated for physical parameters like pH, spreadability and in vitro drug diffusion. Hydrogel loaded with ketoconazole microsponges showed desirable physical properties and in vitro drug release, i.e. 54.66% in 6 h, which is more controlled than the gel prepared with the pure drug i.e. 82.64% in 6 h.