DESIGN, GREENSYNTHESIS AND MOLECULAR DOCKING STUDIES OF A NOVEL 2,4,5- TRIPHENYL IMIDAZOLE DERIVATIVE
AbstractThe design and synthesis of a novel 2,4,5- Triphenyl imidazole derivative has been achieved using a green chemistry approach. These compounds were synthesized by using a sustainable catalytic material and solvent free one-pot reaction where benzil, aromatic aldehydes, ammonium acetate and acid chloride were reacted under microwave irradiation. This method offers several advantages including simplicity, high yields, and short reaction times, making it more environmentally friendly and alternative to conventional methods. The synthesized compounds were characterized by determination of melting point, thin layer chromatography and Fourier transformer infrared spectra. Molecular docking studies were performed to evaluate the binding affinity of the derivative with the proteins 4XMB (Crystal structure of 2, 2′-(naphthalene-1, 4-diylbis (4-methoxyphenyl) sulfonyl) azanediyl) diacetamide bound to human Keap1 Kelch domain)) and 6BIV (HLA-DRB1 in complex with citrullinated LL37 peptide). The docking results indicated that the novel 2,4,5-triphenyl imidazole derivative has significant binding affinity with the protein 4XMB and showed poor binding affinity with the protein 6BIV.
Article Information
16
3548-3554
1405 KB
32
English
IJPSR
Lakshmi Madhavi Chitra *, Sri Sowkhya Taninki, Pushpalatha Kondamuri and Parinaya Sri Lotha
Aditya Pharmacy College, Surampalem, Andhra Pradesh, India.
madhuchitra8@gmail.com
04 July 2024
17 September 2024
24 October 2024
10.13040/IJPSR.0975-8232.15(12).3548-54
01 December 2024
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