DESIGN, SYNTHESIS AND ANTIMICROBIAL ACTIVITY OF NOVEL 1,2,4-TRIAZOLOPHENYL QUINOLINE-2-ONE DERIVATIVES
AbstractHeterocyclic compounds containing triazole ring are important targets in synthetic and medicinal chemistry because this key moiety in responsible for numerous biological activity. An efficient method for synthesis of novel derivatives of Substituted-1,2,4-triazolo phenyl quinolone was adopted by reacting various substituted aniline and cinnamic acid. The synthesized derivatives were designed to have an electron donating and electron with drawing groups to figure out which group is influencing probable pharmacological activity. During designing of the scheme the site of action for activity i.e. disruptions of bacterial cell wall in case of bacteria and interfering with enzymes (cytochrome p450) required for cell membrane synthesis for fungal inhibition was targeted. The structures of these newly synthesized compounds were established by their Elemental analysis, IR, 1H NMR and Mass spectral data. All the synthesized compounds were then evaluated for their antimicrobial potentials using standard drug fluconazole and clotrimazole for antifungal activity and ampicillin anhydride for antibacterial activity. Moderate to good antimicrobial activity was presented by the targeted final derivatives (3a-3j) against pathogenic fungal and bacterialstrains
Article Information
38
4415-23
922
1437
English
Ijpsr
Swagatika Ghosh, Amita Verma *, Alok Mukerjee and Milan Kumar Mandal
Department of Pharmaceutical Sciences, Faculty of Health Sciences, Sam Higginbottom Institute of Agriculture, Technology & Sciences, Allahabad, Uttar Pradesh, India
amitaverma.dr@gmail.com
26 March, 2015
25 May, 2015
15 July, 2015
10.13040/IJPSR.0975-8232.6(10).4415-23
01 October, 2015
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