DESIGN, SYNTHESIS AND ANTIVIRAL ACTIVITY OF 2-{[(2E)-3-(3, 4, 5-MONO/DI/TRI HYDROXYPHENYL) PROP-2-ENOYL] SULFANYL/AMINO} PROPANOIC ACIDS IN HUMAN PLASMA BY ROTOR GENE-Q (5 PLEX) REAL TIME PCR METHOD
AbstractHalfmer of chicoric acid derivatives in two series were planned to synthesized and evaluated for their capacity to reduce the viral load in the human plasma by ROTOR GENE-Q (5 Plex) Real Time PCR method to check their biological activity. Different substituted hydroxy cinnamic acids has been conjugated with different amino acid in N-series and in K-Series same substituted hydroxy cinnamic acids has been conjugated with thio derivative of same amino acids In Anti-HIV evaluation K series (Containing Sulfur as a linker) was found to be have highest activity in terms of in-vitro viral load. Compound K-11 (2-{[(2E)-3-(4-hydroxyphenyl) prop-2-enoyl]-sulfanyl}propanoic acid) was found to be most active with viral load 72 copies/ml and 91.69% decrease in viral load. Among two series K (Mercapto series) is more active and among all compounds K-11 is most active compounds against HIV-1 virus in terms of viral load. So, the activities of compounds constitute a strong rationale for further investigation.
Article Information
31
4865-4875
715KB
1127
English
IJPSR
Nadim M. R. Chhipa ⃰ and Dhrubo Jyoti Sen
Postgraduate Research Laboratory, Department of Pharmaceutical Chemistry, Shri Sarvajanik Pharmacy College, Gujarat Technological University, Arvind Baug, Mehsana-384001, Gujarat, India.
chhipa.nadim7@gmail.com
22 February, 2014
11 June, 2014
30 July, 2014
http://dx.doi.org/10.13040/IJPSR.0975-8232.5(11).4865-75
01 November, 2014
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