DESIGN, SYNTHESIS AND VIRTUAL SCREENING OF CERTAIN 2-PYRAZOLIN-5-ONE AND PYRAZOLIDINE-3, 5-DIONE DERIVATIVES AS POTENTIAL PPAR AGONISTS
AbstractIn the quest for novel PPARg agonists as putative drugs for the treatment of type 2 diabetes, a new series of 2-pyrazolin-5-one and pyrazolidine-3, 5-dione derivatives, were designed and synthesized, as analogues to the anti-diabetic thiazolidinedione agents (TZDs). Extensive molecular modeling studies for the designed molecules were performed; including their compare-fit studies on the generated and validated PPARg agonist’s hypothesis and their molecular docking on the binding sites of the 3D structure of the PPARg receptors.
Article Information
28
3746-3757
829KB
1135
English
Ijpsr
Mohamed A. H. Ismaila,*, Dalal A. Abou El Ella, Khaled A. M. Abouzid, and Maiy Jaballah
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Ain Shams University, El Khalifa ElMaamoon St., 11566, Abbasseya, Cairo, Egypt
mhismaeel@yahoo.com
27 May, 2012
22 August, 2012
26 September, 2012
http://dx.doi.org/10.13040/IJPSR.0975-8232.3(10).3746-57
01 October, 2012
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