DETERMINATION OF DRUGS BASED ON OXIDATION BYALKALINE KMNO4: A KINETIC SPECTROPHOTOMETRIC STUDY

Simple, accurate and precise spectrophotometric methods for quantitative determination of four drugs viz., Alfuzosin (ALF), Esomeprazole (ESO), Indomethacin (IND), Ketorolac Tromethamine (KET) have been developed based on oxidation of the drugs by alk.KMnO₄. Kinetics of the oxidation reaction is followed spectrophotometrically, as one of the reaction product, Mn(VI), absorbed at 610 nm. Initial rate and fixed time method are used for the construction of calibration curves Beer’s law is obeyed in the range 12.5-100µg mL^-1 for ALF; 25-150 µg mL^-1 for ESO; 2.5-15 µg mL^-1 for IND and 6.25-37.5 µg mL^-1 for KET. Recovery studies using pure samples and pharmulations in the Beer’s Law limits have been carried out and the methods have been validated in terms of ICH guidelines. Statistical analysis in terms of student’s t- test and variance F- test demonstrate high accuracy and precision and suggest the methods can be applied in bulk drug and pharmaceutical industries.Simple, accurate and precise spectrophotometric methods for quantitative determination of four drugs viz., Alfuzosin (ALF), Esomeprazole (ESO), Indomethacin (IND), Ketorolac Tromethamine (KET) have been developed based on oxidation of the drugs by alk.KMnO₄. Kinetics of the oxidation reaction is followed spectrophotometrically, as one of the reaction product, Mn(VI), absorbed at 610 nm. Initial rate and fixed time method are used for the construction of calibration curves Beer’s law is obeyed in the range 12.5-100µg mL^-1 for ALF; 25-150 µg mL^-1 for ESO; 2.5-15 µg mL^-1 for IND and 6.25-37.5 µg mL^-1 for KET. Recovery studies using pure samples and pharmulations in the Beer’s Law limits have been carried out and the methods have been validated in terms of ICH guidelines. Statistical analysis in terms of student’s t- test and variance F- test demonstrate high accuracy and precision and suggest the methods can be applied in bulk drug and pharmaceutical industries.