DEVELOPMENT AND CHARACTERIZATION OF POLY (ε-CAPROLACTONE) MICROSPHERES CONTAINING ACETAZOLAMIDEAbstract
The aim of this study was to prepare and evaluate poly(ε-caprolactone) (PCL) microspheres containing acetazolamide. Microspheres were prepared by solvent evaporation method. The influence of formulation factors (polymer: drug ratio, aqueous: oil phase ratio, concentration of aqueous phase, stirring speed and stirring time) on morphology, particle size, encapsulation and recovery efficiency were investigated. The microspheres were spherical with a mean diameter of 99.09±1.71μm, the encapsulation efficiency was 75.28±0.97% (w/w) and the recovery efficiency was 88.23±1.06% (w/w). In vitro release studies revealed a controlled release of acetazolamide from PCL microspheres suitable for peroral administration. In conclusion, PCL microspheres containing acetazolamide were successfully prepared by using solvent evaporation method with the selection of appropriate experimental conditions.