DEVELOPMENT AND CHARACTERIZATION OF POLYMERIC MICROPARTICLES CONTAINING MURRAYA KOENIGII LEAVES EXTRACT FOR MANAGEMENT OF DIABETES MELLITUS

Objective: Formulation and development of polymeric microparticles containing murrayanol for better treatment of diabetes mellitus. Methods: Successive solvent extraction of leaves of Murraya koenigii plant was done. The active constituent of leaves that is murrayanol was isolated and identified through HPLC and FTIR. Polymeric microparticles were selected as a carrier system and formulated by the solvent evaporation method. Characterization and performance evaluation of particulate system loaded with herbal plant extract of the Murraya koenigii leaves was done. Results: These results suggest that the polymeric microparticles are not only effective in the rapid attainment of high drug concentration in the body and also maintain the same over a prolonged period of time. Microparticles were formulated and characterized for the particle size, shape and its distribution, percentage drug entrapment and in-vitro drug release profile along with the stability studies. In-vivo tissue distribution studies on albino rats suggested the accumulation of formulations in the different organs. Conclusion: Prolonged release of natural drug from the carrier system, decrease the dosing frequency and also decrease the dose size.  Better results than marketed synthetic anti-diabetic drugs.